Results 101 to 110 of about 1,437,301 (294)
Taiyuan Ligong Daxue xuebaoPurposes A novel type of Ni2CoCr0.5Si0.3Al0.1Ti0.1 medium entropy alloy is designed in this work. Methods Trace amounts of Si, Al, and Ti elements are added to the non-equiatomic ratio NiCoCr-based medium entropy alloy, and dispersed coherent L12 phase ...
LUO Shunhui +5 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
MicroorganismsWastewater treatment plants (WWTPs) may serve as hotspots for pathogens and promote antimicrobial resistance (AMR). Plastic debris in wastewater could further contribute to AMR dissemination. The aim of this study was to investigate the impact of various
Tam Thanh Tran +4 more
doaj +1 more source
Aging hardening characteristic and electrical conductivity of Cu-Cr-Zr-Mo in situ composite
Science and Engineering of Composite Materials, 2016 Cu-0.85Cr-0.5Zr-0.5Mo in situ composite was prepared by continuous casting, cold drawing, and aging treatment. By means of the analysis of microhardness, electrical conductivity, and transmission electron microscopy, the aging characteristics and ...
Wang Song +4 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Journal of Japan Institute of Light Metals, 1955 Two-steps ageing treatment, as the author calls it, is a heat-treatment to change ageing temperature during its process. As the number and the stable size of the precipitate or pseudo-precipitate differs with the temperature of ageing the distribution of the precipitate or pseudo-precipitate can be changed by such treatment within a wide range, and ...
openaire +2 more sources
Old ideas from a new philosophical model: levels and means of human life extension [PDF]
, 2018 Since 2000, the possibility of extending human lifespan has been a highly debated topic by both biomedical scientists (de Grey and Rae, 2007; Olshansky & Carnes, 2002) and philosophers (Agar, 2010; Overall, 2003).
Garcia-Barranquero, Pablo
core
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. [PDF]
, 2019 Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules.
Andersen, Julie +8 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Applied SciencesThe mechanical properties of beta titanium alloys can be improved by precipitating the α phase in the β-phase matrix and controlling the microstructure via appropriate aging treatments.
Seung-Woo Lee +4 more
doaj +1 more source