Results 121 to 130 of about 694,962 (317)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Advancements in Anti-Aging Treatment Development. [PDF]

Int J Mol Sci, 2023
Picca A, Marzetti E.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stroke, prevention and treatment.

, 2000
"June 2000"--P.
National Institute on Aging.
core  

Effect of Aging Treatment on the Mechanical Properties and Impact Abrasive Wear Property of High-Manganese Steel

High manganese steel can improve its microstructure after aging treatment, which is beneficial for enhancing strength, toughness, and wear resistance. This study aims to explore the effect of aging treatment on mechanical properties and wear resistance ...
Xiangyu Qi, Xiao Han, Xin Yang, Ling Yan, Yu Xin, Xiya Qiao   +5 more
core   +1 more source

Late-onset hypogonadism (LOH) : an emerging pathophysiological entity requiring the physician's attention [PDF]

, 2006
Late-onset hypogonadism (LOH) is an emerging pathophysiological entity. Not everybody is familiar with LOH or even recognizes its existence. Since the 19th century women's life expectancy has become progressively greater than that of men and therefore ...
Nieschlag, Eberhard
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Oral treatment with the herbal formula B401 protects against aging-dependent neurodegeneration by attenuating oxidative stress and apoptosis in the brain of R6/2 mice

, 2015
Sheue-Er Wang,1,2 Ching-Lung Lin,1 Chih-Hsiang Hsu,1 Shuenn-Jyi Sheu,3 Chung-Hsin Wu1 1Department of Life Science, National Taiwan Normal University, Taipei, 2Department of Pathological Inspection, Saint Paul’s Hospital, Taoyuan, 3Brion Research ...
Sheu SJ, Lin CL, Wu CH, Hsu CH, Wang SE
core  

SIRT1-mediated ER beta suppression in the endothelium contributes to vascular aging

, 2016
SIRT1 has many important molecular functions in aging, and the estrogen receptors (ERs) have a vasculoprotective effect, although the detailed mechanism for the roles of SIRT1 and ERs in vascular aging remains unclear. We found that ER beta expression in
Huang, Xiaodong, Li, Min, Liu, Zhaoyu, Ding, Yuanling, Li, Huawen, Wang, Shixuan, Liu, Zhengxiang, Zhang, Laxi, Yao, Paul, Luo, Aiyue, Zhang, Zhefan, Kong, Danli, Wang, Yifei, Ding, Ting, Zhan, Ying, Yu, Haibing, Zhang, Dongwei, Zhang, Hongyu   +17 more
core   +1 more source

Effect of Aging Temperature on Microstructure, Mechanical, and Wear Properties of 18Ni-300 Maraging Steel Produced by Powder Bed Fusion

Metals
Additive manufacturing technologies for metallic materials based on powder bed fusion have enormous industrial potential. In this study, we manufactured 18Ni-300 maraging steel using the powder bed fusion (PBF) process and investigated the effects of ...
Nawon Kwak, Yujin Lim, Seokha Heo, Chami Jeon, Ilguk Jo   +4 more
doaj   +1 more source