Results 141 to 150 of about 694,962 (317)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of the Solid Solution and Aging Treatment on the Mechanical Properties and Microstructure of a Novel Al-Mg-Si Alloy. [PDF]

Materials (Basel), 2023
Chen Y, Wei W, Zhao Y, Shi W, Zhou X, Rong L, Wen S, Wu X, Gao K, Huang H, Nie Z.   +10 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Chronic beta-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat

, 2011
Selective β -adrenoceptor antagonists are part of standard therapy to prolong survival in human heart failure. This study has measured structural, functional, and electrical changes in the cardiovascular system of aging male spontaneously hypertensive ...
Andrew Hoey, Lindsay Brown, Vincent Chan, Andrew Fenning, Hoey, Andrew, Brown, Lindsay, Chan, Vincent, Fenning, Andrew   +7 more
core   +1 more source

Effect of Aging Treatment on the Microstructure and Properties of 2.2 GPa Tungsten-Containing Maraging Steel. [PDF]

Materials (Basel), 2023
Han S, Li X, Liu Y, Geng R, Lei S, Li Y, Wang C.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Cancer and the social induction of aging

, 2011
Age has long been known as the primary population 'risk factor' for cancer. We suggest that the observed disparities in hormonal cancers by ethnicity, gender, and other indices of social structure and power relationships, imply a differential ...
Rodrick Wallace, Deborah Wallace
core  

A Study on the Mechanical Behavior and Deformation Mechanism of the Aged Ni2CoCr0.5Si0.3Al0.1Ti0.1 Medium Entropy Alloy

Taiyuan Ligong Daxue xuebao
Purposes A novel type of Ni2CoCr0.5Si0.3Al0.1Ti0.1 medium entropy alloy is designed in this work. Methods Trace amounts of Si, Al, and Ti elements are added to the non-equiatomic ratio NiCoCr-based medium entropy alloy, and dispersed coherent L12 phase ...
LUO Shunhui, CHANG Hui, WANG Qiang, ZHANG Jiaxin, ZHANG Tuanwei, WANG Zhihua   +5 more
doaj   +1 more source

Improving Precipitation in Cryogenic Rolling 6016 Aluminum Alloys during Aging Treatment. [PDF]

Materials (Basel), 2023
Wang X, Liu Y, Huang Y.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source