Results 161 to 170 of about 694,962 (317)

Osteoporosis in the aging male: Treatment options

, 2008
Stephen P Tuck1, Harish K Datta21Departments of Rheumatology, James Cook University Hospital, Marton Road, Middlesbrough, Cleveland, UK; 2School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne ...
Stephen P Tuck, Harish K Datta
core  

Effect of Si, Mn, Be and Sr Addition on the Tensile Properties of 6061 Type Alloys: Role of Aging Treatment. [PDF]

Materials (Basel), 2023
Samuel AM, Elsharkawi EA, Abdelaziz MH, Samuel E, Samuel FH.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Role of Mg Content and Aging Treatment on the Tensile and Fatigue Properties of Die-Cast 380 Alloy. [PDF]

Materials (Basel), 2022
Samuel AM, Zedan Y, Elsharkawi EA, Abdelaziz MH, Samuel FH.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Artificial Aging Treatment on the Mechanical Properties and Regulation of Precipitated Phase Particles of High-Pressure Die-Cast Thin-Wall AlSi10MnMg Longitudinal Carrier. [PDF]

Materials (Basel), 2023
Zhao X, Wang P, Yang Y, Wang S, Zhao Q, Sun J.   +5 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The Aging Behavior of Polyvinyl Chloride Microplastics by UV/Sodium Percarbonate Oxidation: Efficiency and Mechanism

The aging behavior of microplastics (MPs) in the environment has garnered significant attention, yet the exact aging process undergone by microplastics during advanced oxidation still remains unclear.
Yan Wu, Jia He, Qingguo Wang, Luhan Su, Zhongwen Liu   +4 more
core   +1 more source

Effect of Aging Treatment on Microstructural Evolution and Mechanical Properties of the Electron Beam Cold Hearth Melting Ti-6Al-4V Alloy. [PDF]

Materials (Basel), 2022
Yu J, Yin Z, Huang Z, Zhao S, Huang H, Yu K, Zhou R, Xiao H.   +7 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source