Results 101 to 110 of about 694,962 (317)

Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies [PDF]

, 2019
Aging is associated with multiple molecular and functional changes in haematopoietic cells. Most notably, the self-renewal and differentiation potential of hematopoietic stem cells (HSCs) are compromised, resulting in myeloid skewing, reduced output of ...
Sonja C. Buisman, de Haan, Gerald, Gerald de Haan, de Haan, Gerald; id_orcid, Buisman, Sonja C.   +4 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

NAD + supplementation rejuvenates aged gut adult stem cells

, 2019
The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function assessed ...
Toshimasa Yamauchi, Jaksch, Frank, Frank Jaksch, Masaki Igarashi, Miura, Masaomi, Yamauchi, Toshimasa, Takashi Kadowaki, Igarashi, Masaki, Kadowaki, Takashi, Eric Williams, Guarente, Leonard Pershing, Williams, Eric O, Masaomi Miura, Leonard Guarente   +13 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Expert Consensus on Prevention and Treatment of Aging-Related Gonadal Dysfunction [PDF]

Aging -related hypogonadism involves complex mechanisms in humans, predominantly relating to the decline of multiple hormones and senile gonads. Late -onset hypogonadism (LOH) and erectile dysfunction (ED) are the main manifestations in men, while ...
Wen, Junping, Yan, Zhaoli, Mao, Jiangfeng, Han, Qin, Jin, Kunlin, Caruso, Calogero, Jiang, Sheng, Wu, Xueyan, Zhao, Robert Chunhua, Min, Kyung-Jin, Tian, Long, Deng, Shan, Huang, Boxian, Ma, Li, Stambler, Ilia, Wang, Xi, Su, Huanxing   +16 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of Cold Deformation and Heat Treatments on the Microstructure and Properties of Fe-15Cr-25Ni Superalloy Cold-Drawn Bars

Nanomaterials
The combination of cold deformation and solution aging is an important technological route for the bar processing of superalloy fasteners. The microstructure evolution and mechanical properties are intimately related to the process parameters.
Yunfei Zhang, Zhen Zhang, Zhiyan Sun, Yingli Zhao, Yi Cui, Zhongwu Zhang   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Assisted Outpatient Treatment Program / presented by Drew Adkins, Commissioner, Behavioral Health Services, Kansas Department for Aging and Disability Services.

"January 10, 2024." Presentation before the Kansas Legislature, Senate Judiciary Committee, by Drew Adkins, Commissioner, Behavioral Health Services, Department for Aging and Disability Services.Presentation concerning "Assisted Outpatient Treatment ...
Adkins, Drew.
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