Results 81 to 90 of about 1,437,301 (294)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

Cardiovascular Diabetology
Background Compelling evidence suggests that calcium/phosphorus homeostasis-related parameters may be linked to diabetes mellitus and cardiovascular events.
Jiao Bi, Mei Zheng, Ke Li, Siwei Sun, Zihang Zhang, Nana Yan, Xueping Li   +6 more
doaj   +1 more source

PENGARUH PEMBERIAN SUPLEMENTASI SUPEROXIDE DISMUTASE (SOD) TERHADAP KADAR ALBUMIN SERUM PADA LANSIA [PDF]

, 2015
Background: Levels of serum albumin can be used as a predictor of morbidity and mortality in the elderly. Reduced serum albumin concentration can be caused by oxidative modification due to aging or insufficient protein intake.
Nalaresi, Andyta, Ngestiningsih, Dwi, Setyawati, Amalia N   +2 more
core  

A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment. [PDF]

, 2015
Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence.
Hsu, Chung Y, Liao, Chien-Chang, Lin, Jaung-Geng, Morisky, Donald E, Shih, Chun-Chuan, Su, Yi-Chang, Sun, Mao-Feng, Sung, Fung-Chang, Wen, Chi-Pang   +8 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Effect of Aging Temperature on Microstructure, Mechanical, and Wear Properties of 18Ni-300 Maraging Steel Produced by Powder Bed Fusion

Metals
Additive manufacturing technologies for metallic materials based on powder bed fusion have enormous industrial potential. In this study, we manufactured 18Ni-300 maraging steel using the powder bed fusion (PBF) process and investigated the effects of ...
Nawon Kwak, Yujin Lim, Seokha Heo, Chami Jeon, Ilguk Jo   +4 more
doaj   +1 more source

Microstructure of Al-5Cu-1Li-0.6Mg-0.5Ag-0.5Mn Alloys

Metals, 2020
Microstructural optimization of Al-Li alloys plays a key role in the adjustment of mechanical properties as well as corrosion behavior. In this work, Al-5Cu-1Li-0.6Mg-0.5Ag-0.5Mn alloy was homogenized at different temperatures and holding times, followed
Wenzheng Chen, Wenlong Zhang, Dongyan Ding, Daihong Xiao   +3 more
doaj   +1 more source

Pengaruh Secondary Aging Treatment terhadap Sifat Mekanik dan Surface Glossiness pada Aluminium Paduan 7003 [PDF]

, 2017
As technology advances and the quality of life improves, there is a deep need that requires of aluminium alloy that bears high strength, high toughness, high surface glossiness, anti-corrosion, and high fatigue resistivity [2].
Ramli, R. (Ramli)
core  

Surface roughened zirconia: towards hydrothermal stability [PDF]

, 2015
Surface roughness is needed in several yttria-stabilized zirconia components used in restorative dentistry for osseointegration or adhesion purposes. This can be achieved by different treatments, which may also modify the microstructure of the surface ...
Anglada Gomila, Marcos Juan, Camposilvan, Erik, Flamant, Quentin   +2 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source