Results 131 to 140 of about 150,883 (335)

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Role of nasal microbiota in regulating host anti-influenza immunity in dogs

Microbiome
Background Numerous studies have confirmed a close relationship between the pathogenicity of influenza and respiratory microbiota, but the mechanistic basis for this is poorly defined.
Jinzhu Geng, Yuhao Dong, Hao Huang, Xia Wen, Ting Xu, Yanbing Zhao, Yongjie Liu   +6 more
doaj   +1 more source

Nuture : quarterly newsletter of the National Children\ue2\u20ac\u2122s Center for Rural and Agricultural Health and Safety ; Vol. 17, issue 2

The National Children\ue2\u20ac\u2122s Center for Rural and Agricultural Health and Safety strives to enhance the health and safety of all children exposed to hazards associated with agricultural work and rural environments.Funds for this newsletter are ...

core  

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Nurture : newsletter of the National Children\u2019s Center for Rural and Agricultural Health and Safety ; v. 21, issue 2

Funds for this newsletter are provided by the National Institute for Occupational Safety and Health (NIOSH award no.

core   +1 more source

Progesterone interferes with microtubule-dependent cell division in Toxoplasma gondii

Parasites & Vectors
Background Toxoplasma gondii is an opportunistic intracellular parasite that can cause severe reproductive disorders during pregnancy. Progesterone is markedly elevated during pregnancy and has been shown to affect the replication of T. gondii.
Zhili Shan, Zifu Zhu, Na Yang, Yanqun Pei, Jing Liu, Yong Fu, Qun Liu   +6 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Dynamic distribution of Paneth cells in pig intestine under normal and infection conditions

BMC Veterinary Research
Paneth cells, a type of intestinal epithelial cell, are primarily located at the base of the intestinal crypts and adjacent to intestinal stem cells. They play a crucial role in maintaining the intestinal mucosal barrier by regulating the gut microbiota ...
Xiaojing Cui, Ruiling Liu, Yixuan Wu, Yi Chen, Qingyu Gao, Jie Zhou, Yunlei Cao, Junjun Yang, Qian Yang   +8 more
doaj   +1 more source

Gasdermin B-mediated pyroptosis as a host defense against swine enteric coronaviruses and its antagonism by PEDV

mBio
Gasdermin B (GSDMB), a member of the spore-forming protein gasdermin (GSDM) family, is critical for inflammation and immunity and has been genetically linked to human diseases.
Yao Yao, Ning Huang, Xinyu Huang, Mengqi Yuan, Li Kang, Yanlong Ma, Jun Han, Guozhong Zhang, Pinghuang Liu   +8 more
doaj   +1 more source

Nurture : newsletter of the National Children\u2019s Center for Rural and Agricultural Health and Safety ; v. 24, issue 1

National Children\u2019s Center marks 25 yearsThe U.S. Congress provided targeted funding to the National Institute for Occupational Safety and Health in 1997 to implement a National Childhood Agricultural Injury Prevention Initiative.

core