Results 221 to 230 of about 20,021 (258)

Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress. [PDF]

J Neuroendocrinol
Gueissaz L, Sideromenos S, Tretiakov EO, Schnell R, Harkany T.   +4 more
europepmc   +1 more source

Epigenetic modification of hypothalamic neuropeptides and metabolic hormone receptors in metabolic health. [PDF]

Front Endocrinol (Lausanne)
Oladun B, Mall S, Kim MH.
europepmc   +1 more source

The impact of Asic2 deletion on metabolic homeostasis in mice. [PDF]

Physiol Rep
Hamby M, Kaur J, Lirette S, do Carmo JM, Speed J, Islam T, Hildebrandt E, Barr E, Challagundala L, Drummond HA.   +9 more
europepmc   +1 more source

Early diagnosis of Alzheimer's disease using machine learning and blood biomarkers. [PDF]

BMC Med Inform Decis Mak
Yan G, Wu S, Qian Q, Alzheimer’s Disease Neuroimaging Initiative.   +3 more
europepmc   +1 more source

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AgRP neurons encode circadian feeding time

Nature Neuroscience, 2023
Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out physiological energetic state and elicit feeding, but the regulation of these neurons across daily timescales is poorly understood.
Nilufer Sayar-Atasoy, Iltan Aklan, Yavuz Yavuz, Connor Laule, Hyojin Kim, Jacob Rysted, Muhammed Ikbal Alp, Debbie Davis, Bayram Yilmaz, Deniz Atasoy   +9 more
openaire   +2 more sources

AgRP signalling negatively regulates bone mass

Journal of Neuroendocrinology, 2021
AbstractThe central nervous system is an active and major regulator of bone structure and remodelling. Specifically, signalling within the hypothalamus has been shown to be critical to ensuring that skeletal functions align with whole body metabolic supply and demand. Here, we identify agouti‐related peptide (AgRP), an orexigenic peptide exclusively co‐
Ronaldo F. Enriquez, Nicola J. Lee, Herbert Herzog   +2 more
openaire   +2 more sources

Opioidergic Regulation of AgRP Neurons

Physiology, 2023
Opioids are generally known to promote hedonic consumption. Although much of the existing evidence is primarily based on studies in mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite circuits; however, their role in homeostatic feeding remains unclear.
Deniz Atasoy, Nilufer Sayar Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Iltan Aklan, Lin Tian   +7 more
openaire   +1 more source

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP [PDF]

Cell Metabolism, 2013
Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA ...
Michael J Krashes, Bhavik P Shah, Bradford Lowell   +2 more
exaly   +3 more sources

Palatability Can Drive Feeding Independent of AgRP Neurons [PDF]

Cell Metabolism, 2015
Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity ...
Emily S Webber, Fanny Langlet, Marie Schaeffer   +2 more
exaly   +8 more sources

Starving for AGRP

Nature Reviews Neuroscience, 2012
Activation of hypothalamic agouti-related protein (AGRP)-expressing neurons is known to increase food intake in rodents. Here, Atasoy et al., using channel rhodopsin-assisted circuit mapping and pharmacogenetic techniques, showed that activation of inhibitory projections of AGRP neurons to a small population of oxytocin-expressing neurons in the ...
openaire   +1 more source