Results 101 to 110 of about 688,717 (308)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Peer Review #2 of "A review of microscopic analysis of blood cells for disease detection with AI perspective (v0.1)"

, 2021
Nilkanth Mukund Deshpande, Shilpa Gite, Rajanikanth Aluvalu, Shilpa Gite, Vithalrao Patil, S Shilpa, Gite, S Abbas, M Abbasi, S Kermani, A Tajebib, M Amin, M Abbasi, V Acharya, P Kumar, S Agaian, M Madhukar, A Chronopoulos, N Ahmed, A Yigit, Z Isik, A Alpkocak, A Ahuja, F Al-Obeidat, A Tubaishat, B Shah, Z Halim, F Al-Tahhan, A Sakr, D Aladle, M Fares, M Alom, C Yakopcic, T Taha, V Asari, S Bhagavathi, S Thomas Niba, L Bhavnani, K Jaliya, U, J Joshi, M, S Biswas, D Ghoshal, Chin Neoh, S Srisukkham, W Zhang, L Todryk, S Greystoke, B Lim, C Hossain, M Aslam, N, Duan, I Livieris, H Elsalamony, Z Halim, O Ali, G Khan, Z Halim, Z Halim, T Muhammad, B Houwen, S Iqbal, Z Halim, B Javidi, A Markman, S Rawat, T O'connor, A Anand, B Andemariam, K Jha, H Dutta, K Jha, H Dutta, R Labati, V Piuri, F Scotti, A Lundervold, A Lundervold, C Matek, S Schwarz, K Spiekermann, C Marr, H Miao, C Xiao, S Mishra, B Majhi, P Sa, Z Moshavash, H Danyali, M Helfroush, A Negm, O Hassan, A Kandil, N Patel, A Mishra, N Patel, A Mishra, V Phung   +99 more
openalex   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Chemotaxis to self-generated AI-2 promotes biofilm formation in Escherichia coli

Microbiology, 2017
Responses to the interspecies quorum-sensing signal autoinducer-2 (AI-2) regulate the patterns of gene expression that promote biofilm development. Escherichia coli also senses AI-2 as a chemoattractant, a response that requires the periplasmic AI-2-binding protein LsrB and the chemoreceptor Tsr.
Sneha, Jani, Andrew L, Seely, George L, Peabody V, Arul, Jayaraman, Michael D, Manson   +4 more
openaire   +2 more sources

Screening Rules for Convex Problems [PDF]

, 2016
We propose a new framework for deriving screening rules for convex optimization problems. Our approach covers a large class of constrained and penalized optimization formulations, and works in two steps.
Gärtner, Bernd, Jaggi, Martin, Olbrich, Jakob, Raj, Anant, Schölkopf, Bernhard   +4 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Wi-Fi Fingerprint Indoor Localization by Semi-Supervised Generative Adversarial Network

Sensors
Wi-Fi fingerprint indoor localization uses Wi-Fi signal strength measurements obtained from a number of access points. This method needs manual data collection across a positioning area and an annotation process to label locations to the measurement sets.
Jaehyun Yoo
doaj   +1 more source

Regulation of Yersina pestis Virulence by AI-2 Mediated Quorum Sensing [PDF]

, 2010
The proposed research was motivated by an interest in understanding Y. pestis virulence mechanisms and bacteria cell-cell communication. It is expected that a greater understanding of virulence mechanisms will ultimately lead to biothreat countermeasures and novel therapeutics. Y.
Segelke, B, Hok, S, Lao, V, Corzett, M, Garcia, E   +4 more
openaire   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source