Results 91 to 100 of about 688,717 (308)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Constructing Separable Arnold Snakes of Morse Polynomials
, 2019 We give a new and constructive proof of the existence of a special class of univariate polynomials whose graphs have preassigned shapes. By definition, all the critical points of a Morse polynomial function are real and distinct and all its critical ...
Sorea, Miruna-Stefana
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Effects of shear rate on strength properties and pile-soil interface of marine soft clay
Yantu gongcheng xuebao, 2017 The CU triaxial tests and ring shear tests on interface between steel pipe pile and soil of a kind of intact marine soft clay with medium structure are carried out under influence of shear strain rate, and the variations of strength properties and pile ...
KONG Ling-wei 1, XIONG Chun-fa 1, 2, GUO Ai-guo 1, YANG Ai-wu 1, 3
doaj +1 more source
Artificial Intelligence-Assisted Loop Mediated Isothermal Amplification (AI-LAMP) for Rapid Detection of SARS-CoV-2 v1 [PDF]
, 2020 Don C Cooper
openalex +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
AI-2 Signaling: A Potential Driver of Bacteremia in Non-Typhoidal Salmonella Infections
Infection and Drug ResistanceYu Li,1,2,* Bing Lu,1,3,* Xinhua Qiang,3 Yibin Lin,1 Jie He,2 Yunxiang Cai3 1School of Medicine, Huzhou University, Huzhou, Zhejiang, 313000, People’s Republic of China; 2Department of Infectious Diseases, First Affiliated Hospital of Huzhou ...
Li Y, Lu B, Qiang X, Lin Y, He J, Cai Y
doaj
Materials & DesignMagnetoelectric nanoparticles (MENs) are emerging as promising candidates for wireless and minimally invasive deep brain stimulation, yet rational design strategies to maximize their magnetoelectric (ME) efficiency remain elusive.
Gawtak Kim +3 more
doaj +1 more source