Results 91 to 100 of about 98,954,750 (292)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Climate Change and AI. Recommendations for Government Action

, 2022
The report, Climate Change and AI: Recommendations for Government, highlights 48 specific recommendations for how governments can both support the application of AI to climate challenges and address the climate-related risks that AI ...
Rolnick, David, Donti, Priya L., Clutton-Brock, Peter, Kaack, Lynn   +3 more
core  

AI-2 Signaling: A Potential Driver of Bacteremia in Non-Typhoidal Salmonella Infections

Infection and Drug Resistance
Yu Li,1,2,* Bing Lu,1,3,* Xinhua Qiang,3 Yibin Lin,1 Jie He,2 Yunxiang Cai3 1School of Medicine, Huzhou University, Huzhou, Zhejiang, 313000, People’s Republic of China; 2Department of Infectious Diseases, First Affiliated Hospital of Huzhou ...
Li Y, Lu B, Qiang X, Lin Y, He J, Cai Y
doaj  

Periodicity-Driven Adaptive Localization of Respiratory Regions for Non-Contact Respiration Monitoring in Sleeping Infants

Bioengineering
Respiration is a critical vital sign for assessing the health status of infants during the first year of life. Conventional video-based respiratory monitoring methods often rely on manually defined regions of interest (ROIs) targeting specific anatomical
Hyoyeong Jeong, Jinsoo Kim, Eui Chul Lee
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Incorporating LsrK AI‐2 quorum quenching capability in a functionalized biopolymer capsule

Biotechnology and Bioengineering, 2017
AbstractAntibacterial resistance is an issue of increasing severity as current antibiotics are losing their effectiveness and fewer antibiotics are being developed. New methods for combating bacterial virulence are required. Modulating molecular communication among bacteria can alter phenotype, including attachment to epithelia, biofilm formation, and ...
Rhoads, Melissa K., Hauk, Pricila, Terrell, Jessica Lynn, Tsao, Chen-Yu, Oh, Hyuntaek, Raghavan, Srinivasa R., Mansy, Sheref S., Payne, Gregory F., Bentley, William E.   +8 more
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Numerical model for jointed rock mass in particle flow code and its application

Yantu gongcheng xuebao, 2017
To simulate the joint network around mining tunnels and to conduct the stability analysis of tunnels in jointed rock mass, a numerical model for jointed rock mass containing particle flow block model, original joint network and secondary joint network is
JIN Ai-bing 1, LIU Gang 1, YANG Zhen-wei 2
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source