Results 51 to 60 of about 98,954,750 (292)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
AI and Human Reasoning: Qualitative Research in the Age of Large Language Models [PDF]
Context: The advent of AI-driven large language models (LLMs), such as ChatGPT 3.5 and GPT-4, have stirred discussions about their role in qualitative research. Some view these as tools to enrich human understanding, while others perceive them as threats
Whittle, J, Bano, M, Zowghi, D
core +1 more source
Different tensile tests on difference of strength of frozen soils
Yantu gongcheng xuebao, 2019 The tensile strength of frozen soils is an important index in engineering design. In the tests, it is found that the uniaxial tensile strength of frozen soils is inconsistent with the four-point bending tensile strength.
YU Chang-yi 1, 2, 3, LIU Ai-min 1, 2, 3, GUO Bing-chuan 2, LIU Wen-bin 1, 2, 3
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Lsr‐mediated transport and processing of AI‐2 in Salmonella typhimurium [PDF]
Molecular Microbiology, 2003 SummaryThe LuxS‐dependent autoinducer AI‐2 is proposed to function in interspecies cell–cell communication in bacteria. In Salmonella typhimurium, AI‐2 is produced and released during exponential growth and is subsequently imported into the bacteria via the Lsr (luxS regulated) ATP binding cassette (ABC) transporter.
Michiko E, Taga +2 more
openaire +2 more sources
Estimation of Contact PPG-Derived Vascular Indices from Reconstructed rPPG Signals
SensorsRemote photoplethysmography (rPPG) enables contactless cardiovascular monitoring using conventional cameras; however, its smooth waveform morphology limits the extraction of vascular indices that depend on fine pulse-wave characteristics.
SiJin Kim +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus [PDF]
Journal of Antimicrobial Chemotherapy, 2007 The concern over rising antibiotic resistance necessitates exploration of alternative approaches in antimicrobial therapy. Bacterial communities use the auto-inducer 2 (AI-2) quorum sensing signal at a specific threshold level for intra- and interspecies communication in order to regulate virulence behaviour.
Nibras A A M, Ahmed +2 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Dynamic analysis of pre-stressed elastic plates resting on layered soils
Yantu gongcheng xuebao, 2021 Based on the analytical layer-element method and classical the elastic thin plate theory, a method for solving the vertical dynamic interaction between the layered soils and the pre-stressed elastic plates is proposed.
LIU Chun-lin 1, 2, 3, AI Zhi-yong 2, TANG Meng-xiong 1, HU He-song 1
doaj +1 more source