Results 61 to 70 of about 98,954,750 (292)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Enhanced bioethanol production by Zymomonas mobilis in response to the quorum sensing molecules AI-2 [PDF]

, 2011
The depletion of non-renewable energy resources, the environmental concern over the burning of fossil fuels, and the recent price rises and instability in the international oil markets have all combined to stimulate interest in the use of fermentation ...
Yang, Jung Woo, YANG, JUNG,WOO
core  

Real-Time Detection of At-Risk Movements Using Smartwatch IMU Sensors

Applied Sciences
The issue of personal safety for crime prevention has become a significant societal concern. Existing software on smartwatches developed for personal protection might provide GPS location tracking and emergency reporting, but this is limited to ...
Haeun Oh, Jaehyun Yoo
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Exfoliative Endometrial Cytology in Embryo Donor Cows—Comparison of Sampling Localizations for the Diagnosis of Subclinical Endometritis

Veterinary Sciences, 2016
Subclinical endometritis has a major effect on the reproductive performance of dairy cows and also on the success of embryo collection. Thus it is important to minimize the number of false-negative diagnoses.
Janna Egberts, Jan Detterer, Arno Park, Sabine Meinecke-Tillmann   +3 more
doaj   +1 more source

Investigating a Curcumin-Loaded PLGA-PEG-PLGA Thermo-Sensitive Hydrogel for the Prevention of Alzheimer’s Disease

Antioxidants, 2022
In Alzheimer’s disease (AD), the most common cause of dementia, patients generally forget to take pills or skip medication due to side effects, affecting the treatment efficacy.
Yi-Wen Lin, Chih-Hsiang Fang, Ching-Yun Yang, Ya-Jyun Liang, Feng-Huei Lin   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Temperature, not LuxS, mediates AI-2 formation in hydrothermal habitats. [PDF]

FEMS microbiology ecology, 2009
Quorum sensing provides the basis for coordinating community-wide, microbial behaviors in many mesophilic bacteria. However, little attention has been directed toward the possibility that such phenomena occur in extremely thermal microbial environments.
Jason D, Nichols, Matthew R, Johnson, Chung-Jung, Chou, Robert M, Kelly   +3 more
openaire   +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Innovation Paradox and firm value in global Big Tech: Lag effects and the moderating role of profitability

Journal of Open Innovation: Technology, Market and Complexity
Global Big Tech firms make enormous R&D and capital expenditures (CAPEX) to maintain technological hegemony. However, these investments can undermine firm value in the short term - a phenomenon known as the Innovation Paradox - and the conditions under ...
Young Wan Jin, Taeyeon Oh
doaj   +1 more source