Results 91 to 100 of about 5,919,808 (365)

Design Principles for Generative AI Applications [PDF]

open access: yesInternational Conference on Human Factors in Computing Systems
Generative AI applications present unique design challenges. As generative AI technologies are increasingly being incorporated into mainstream applications, there is an urgent need for guidance on how to design user experiences that foster effective and ...
Justin D. Weisz   +5 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Software redundancy: what, where, how [PDF]

open access: yes, 2017
Software systems have become pervasive in everyday life and are the core component of many crucial activities. An inadequate level of reliability may determine the commercial failure of a software product.
Carzaniga, Antonio   +2 more
core  

Self-Driving Cars, Trolley Problems, and the Value of Human Life: An Argument Against Abstracting Human Characteristics

open access: yesOpen Philosophy
The rise of self-driving cars raises numerous ethical conundrums, none has attracted so much public attention as the question of how to programme AVs in crash scenarios. How does a car respond when difficult, life-and-death choices are to be made?
Milford Stephen R.   +2 more
doaj   +1 more source

Theories and Dimensions of Algorithmic Power, between Agency and Domination

open access: yesScienza & Politica
This article reviews the critical and sociological literature on algorithms and AI in light of anthropocentric social theories of power and its dimensions.
Massimo Airoldi
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Le jeu de rôle "sérieux": un outil pédagogique pour l’EDD et la pensée complexe ? [PDF]

open access: yes, 2015
Les JIES ont accueilli une session expérimentale de « L’empire des hyperplaneurs », un jeu de rôle "sérieux", autour de la problématique des pétroles de schistes.
Bourqui, François   +6 more
core  

AI Betrays AI

open access: yesJournal of Student Research
The rise of AI deepfakes following the launch of ChatGPT and its AI counterpart DALL-E has sparked fear that the boundary between real and fake can no longer be identified. In this study, it was found that machine learning algorithms can be reliably used to distinguish between real and AI-generated images of human faces when provided with high ...
Mike Mao   +2 more
openaire   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

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