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The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson+7 more
wiley +1 more source
The growing integration of artificial intelligence (AI) dialogue systems within educational and research settings highlights the importance of learning aids.
Chunpeng Zhai+2 more
semanticscholar +1 more source
Futur campus santé de Sion: vers une collaboration entre services documentaires? : état des lieux et pistes de réflexion [PDF]
La HES-SO Valais Wallis a pour projet de construire à l’horizon 2020 un nouveau bâtiment regroupant ses formations dans le domaine de la santé (soins infirmiers et physiothérapie) et du social (filières de niveau école supérieure dans l’éducation de l ...
Bressoud Guérin, Valérie+2 more
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Efficacy of acoustic waves in preventing Streptococcus mutans adhesion on dental unit water line [PDF]
Background: nei riuniti odontoiatrici, la qualità dell'acqua utilizzata per la refrigerazione e il risciacquo di manipoli, siringhe e altri componenti è un aspetto di notevole importanza sanitaria.
Berlutti Francesca+5 more
core +1 more source
AI generations: from AI 1.0 to AI 4.0
This paper proposes that Artificial Intelligence (AI) progresses through several overlapping generations: AI 1.0 (Information AI), AI 2.0 (Agentic AI), AI 3.0 (Physical AI), and a speculative AI 4.0 (Conscious AI). Each AI generation is driven by shifting priorities among algorithms, computing power, and data.
Jiahao Wu, Hengxu You, Jing Du
openaire +3 more sources
Novel and unscrutinized immune entities of the zebrafish gut
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil+5 more
wiley +1 more source
A probabilistic approach for building disease phenotypes across electronic health records
Background Identifying the set of patients with a particular disease diagnosis across electronic health records (EHRs), referred to as a phenotype, is an important step in clinical research and applications. However, this task is often challenging, where
David Vidmar+7 more
doaj +1 more source
The Role of AI in Hospitals and Clinics: Transforming Healthcare in the 21st Century
As healthcare systems around the world face challenges such as escalating costs, limited access, and growing demand for personalized care, artificial intelligence (AI) is emerging as a key force for transformation.
Shiva Maleki Varnosfaderani+1 more
semanticscholar +1 more source
Introduction This mixed-methods study evaluates the impact of AI-assisted language learning on Chinese English as a Foreign Language (EFL) students’ writing skills and writing motivation.
Cuiping Song, Yanping Song
semanticscholar +1 more source
Global Solutions vs. Local Solutions for the AI Safety Problem [PDF]
There are two types of artificial general intelligence (AGI) safety solutions: global and local. Most previously suggested solutions are local: they explain how to align or “box” a specific AI (Artificial Intelligence), but do not explain how to prevent ...
Turchin, Alexey
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