Results 61 to 70 of about 4,240,631 (277)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Epidemiology of intensive care unit-acquired sepsis in Italy: results of the SPIN-UTI network [PDF]

, 2018
BACKGROUND: Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units ...
Agodi A, Arrigoni C, Auxilia F, Barchitta M, Brusaferro S, D'Errico MM, Fabiani L, Laurenti P, Mattaliano AR, Montagna MT, Mura I, Orsi GB, Pasquarella C, Squeri R, Tardivo S, Torregrossa MV   +15 more
core   +1 more source

Explainable AI (ex-AI) [PDF]

Informatik-Spektrum, 2018
,,Explainable AI“ ist kein neues Gebiet. Vielmehr ist das Problem der Erklarbarkeit so alt wie die AI selbst, ja vielmehr das Resultat ihrer selbst. Wahrend regelbasierte Losungen der fruhen AI nachvollziehbare ,,Glass-Box“-Ansatze darstellten, lag deren Schwache im Umgang mit Unsicherheiten der realen Welt.
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Human, too human? Experience, Learning, Interaction with AI

Academicus International Scientific Journal
The contribution addresses the topic of interaction with AI with the aim of investigating the importance of interface characteristics for the acceptance of and interaction with produced innovations, with a special focus on social robotics.
Eleonora Sparano
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

AFCC 2023: The Role of the Translator in the Age of AI

Writing Chinese: A Journal of Contemporary Sinophone Literature
The following is a record of the session “The Role of the Translator in the Age of AI” at the Asian Festival of Children’s Content, in Singapore, on 28 May 2023, a few months after the launch of ChatGPT (November 2022).
Helen Wang
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Direct and indirect effects of Gracilaria vermiculophylla on native Fucus vesiculosus [PDF]

, 2013
The perennial red macroalga Gracilaria vermiculophylla (Ohmi) Papenfuss has recently been introduced to the Baltic Sea and is a potential competitor to Fucus vesiculosus, the most common native perennial alga in large parts of the Baltic Sea.
Buchholz, Björn, Hammann, Mareike, Karez, Rolf, Weinberger, Florian   +3 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source