Results 41 to 50 of about 783,920 (240)

Little ai, Big AI—Good AI, Bad AI [PDF]

Research-Technology Management, 2019
The real risk with AI isn’t malice but competence. A super intelligent AI will be extremely good at accomplishing its goals, and if those goals aren’t aligned with ours, we’re in real trouble.
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exploring the Perspectives of Iranian Carpet Designers on Their Career Future in the Face of AI-Based Software [PDF]

پیکره
Introduction: Artificial Intelligence (AI) has become a significant force in reshaping various aspects of social, economic, and industrial life, making it a hallmark of technological advancement and future-oriented thinking. It appears that the domain of
Safa Naghash chirehdast, Bijan Arbabi
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Digital Governance in Local Public Administration: Between Transparency and Hypercontrol [PDF]

Ovidius University Annals: Economic Sciences Series
This paper explores the complex dynamics of digital governance within local public administration, emphasizing how technological innovation simultaneously enhances transparency and enables new forms of algorithmic control. Focusing on municipalities in
Alecsandra Andreea Burcea (Scintee)
doaj  

Neoantigen cancer vaccines: a new star on the horizon

Cancer Biology & Medicine
Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient’s own immune system and eliminate cancer cells.
Xiaoling Li, Jian You, Liping Hong, Weijiang Liu, Peng Guo, Xishan Hao   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Self-Driving Cars, Trolley Problems, and the Value of Human Life: An Argument Against Abstracting Human Characteristics

Open Philosophy
The rise of self-driving cars raises numerous ethical conundrums, none has attracted so much public attention as the question of how to programme AVs in crash scenarios. How does a car respond when difficult, life-and-death choices are to be made?
Milford Stephen R., Elger Bernice S., Shaw David M.   +2 more
doaj   +1 more source

Theories and Dimensions of Algorithmic Power, between Agency and Domination

Scienza & Politica
This article reviews the critical and sociological literature on algorithms and AI in light of anthropocentric social theories of power and its dimensions.
Massimo Airoldi
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source