Results 31 to 40 of about 157,497 (260)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Análisis de la noción de las técnicas subliminales contenida en el artículo 5 (1) (a, b y c) del Reglamento de Inteligencia Artificial de la Unión Europea

Revista Justicia y Derecho
El artículo examina la noción de técnicas subliminales, manipulativas o engañosas intencionadamente perjudiciales que influyen de forma significativa y sustancial en el comportamiento de personas físicas o grupos de personas prohibidas en el Artículo 5.1(
María Isabel Cornejo Plaza
doaj   +1 more source

Complying with the EU AI Act

The EU AI Act is the proposed EU legislation concerning AI systems. This paper identifies several categories of the AI Act. Based on this categorization, a questionnaire is developed that serves as a tool to offer insights by creating quantitative data.
Jacintha Walters, Diptish Dey, Debarati Bhaumik, Sophie Horsman   +3 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

General-purpose AI regulation and the European Union AI Act

Internet Policy Review
This article provides an initial analysis of the EU AI Act's (AIA) approach to regulating general-purpose artificial intelligence (AI) – such as OpenAI's ChatGPT – and argues that it marks a significant shift from reactive to proactive AI governance ...
Oskar J. Gstrein, Noman Haleem, Andrej Zwitter   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The EU AI Act and the Food System: How the European Union Ai Act Applies to Agrifood

European Journal of Risk Regulation
Artificial Intelligence (AI) is increasingly being used in the agrifood sector to improve efficiency, safety and sustainability. The application of the European Union Artificial Intelligence Act’s (AI Act) to the broad spectrum of agrifood AI systems has
Idse Lucien Val
doaj   +1 more source

Preparing for the AI Act

, 2023
A briefing for ML practitioners on the potential impact of the EU's proposed AI Act on AI developers, the risk management apporach taken, the status of the current legislative and associated technical standards development processes and some the the relevant research to support practitioners from the PROTECTm ADAPT and EMPOWER research programmes.
openaire   +2 more sources