Results 41 to 50 of about 157,497 (260)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Truly Risk-based Regulation of Artificial Intelligence How to Implement the EU’s AI Act

open access: yesEuropean Journal of Risk Regulation
The Artificial Intelligence Act (AI Act) of the European Union (EU) claims to be based on a risk-based approach to avoid over-regulation and to respect the principle of legislative proportionality.
Martin Ebers
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Artificial Intelligence Governance Beyond Borders: The EU AI Act’s Influence on Third Party Legal Frameworks and Regional Organizations

open access: yesReview of European and Comparative Law
This research examines the perspective and influence of the European Union’s Artificial Intelligence Act (EU AI Act) on AI regulation in third countries and regional organizations.
Annas Rasid Musthafa   +1 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

AI ACT AND THE ECHO OF ASIMOV'S LAWS OF ROBOTICS. WHEN THE LACK OF LEGAL SOURCES PUSHED THE EU TOWARDS SCIENCE FICTION [PDF]

open access: yesChallenges of the Knowledge Society
We are living in a time of rapid technological advancement, particularly in the field of AI, and more specifically, Generative AI (GAI). As GAI models increasingly permeate everyday life, the urgent need for effective regulation has become apparent. This
Sebastian BĂLĂNICĂ   +1 more
doaj  

Harmonised standards to the AI Act – for medical devices, too

open access: yesFinnish Journal of eHealth and eWelfare
The European Union artificial intelligence act (AI Act) establishes the rules for the application of artificial intelligence (AI) systems within the European Union.
Alpo Olavi Värri
doaj   +1 more source

Generative Ai, Copyright and the Ai Act

open access: yesComputer Law & Security Review
This paper provides a critical analysis of the Artificial Intelligence (AI) Act's implications for the European Union (EU) copyright acquis, aiming to clarify the complex relationship between AI regulation and copyright law while identifying areas of legal ambiguity and gaps that may influence future policymaking. The discussion begins with an overview
openaire   +2 more sources

Imagining the AI landscape after the AI act (Preface) [PDF]

open access: yes, 2023
We provide a summary of the second Workshop on Imagining the AI Landscape after the AI Act (IAIL 2023), co-located with the 2nd International Conference on Hybrid Human-Artificial Intelligence (HHAI 2023), held on June 27, 2023 in Munich, Germany.
Dushi D, Naretto F, Pratesi F
openaire   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

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