Results 41 to 50 of about 2,086,069 (292)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa   +7 more
wiley   +1 more source

AI and Ethics -- Operationalising Responsible AI

open access: yesCoRR, 2021
In the last few years, AI continues demonstrating its positive impact on society while sometimes with ethically questionable consequences. Building and maintaining public trust in AI has been identified as the key to successful and sustainable innovation.
Liming Zhu 0001   +4 more
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Co-design with affect stories and applied ethics for health technologies

open access: yesFrontiers in Communication
The integration of digital health technologies in clinical practices and everyday lives of patients raises several issues. Some of them are related to applied ethics.
Ambre Davat   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Regulación ética de IA: Marcos y buenas prácticas para la equidad y la transparencia

open access: yesTelos: Revista de Estudios Interdisciplinarios en Ciencias Sociales
La pertinencia del estudio se debe a la naturaleza fragmentada de la actual regulación ética y jurídica de la IA, junto con la falta de un modelo unificado de cumplimiento normativo en un contexto de riesgos trans jurisdiccionales.
Viktoriia Riabokon
doaj   +1 more source

The tech industry hijacking of the AI ethics research agenda and why we should reclaim it

open access: yesDiscover Artificial Intelligence, 2022
This paper reflects on the tech industry’s colonization of the AI ethics research field and addresses conflicts of interest in public policymaking concerning AI.
Anne Gerdes
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

L’éthique située de l’IA et ses controverses

open access: yesRevue Française des Sciences de l’Information et de la Communication, 2022
To address the way in which AI affects everyday life, we will position ourselves in a pragmatic approach to ethics, which we will call situated ethics, which seems to us an alternative to the incantatory approaches common to “ethical AI” which arouses a ...
Manuel Zacklad, Antoinette Rouvroy
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

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