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The attribution problem of a seemingly intangible industry

Environmental Challenges
We promote a more comprehensive understanding of the environmental costs associated with AI and “clouds” by raising awareness about the resource and emission-intensive nature of Artificial Intelligence through the use of data centres. While acknowledging
Sophia Falk, Aimee van Wynsberghe, Lisa Biber-Freudenberger   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Ethical gaps in closed-loop neurotechnology: a scoping review

npj Digital Medicine
Closed-loop (CL) neurotechnology, which dynamically adapts to patients’ neural states, offers new opportunities for treating neurological and psychiatric disorders. However, its real-time feedback mechanisms raise critical ethical challenges.
Lea Haag, Georg Starke, Markus Ploner, Marcello Ienca   +3 more
doaj   +1 more source

Empathetic AI for ethics-in-the-small

AI & SOCIETY, 2022
There has been much media attention on the society-wide effects of the rapid and unfettered deployment of AI (by AI, we mean any device/algorithm that uses AI techniques as part of its functioning, not necessarily just self-driving cars, robots, etc.). Most of these have focused on ethics-in-the-large, i.e., concepts like justice, fairness, bias—which ...
Vivek Nallur, Graham Finlay
openaire   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

AI Governance in Healthcare: Best Practices, Solutions, and Unresolved Issues

Telehealth and Medicine Today
What challenges are presented by AI adoption in healthcare? What role should AI governance play in regard to the opportunities and risks for generative AI (large language models like ChatGPT-4, etc.) in health?
Calvin Lawrence, Seth Dobrin, PhD, Gil Alterovitz, PhD, Yoav Schlesinger , Moderator: Dennis Chornenky   +4 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

The Double Helix of Data Extraction

Technology and Regulation
The increasing value of data is rendering data extraction ubiquitous. Looking at recent research, I argue that work critical of extractive dynamics can give rise to a ‘double-helix of data extraction’ that exacerbates existing asymmetries by ...
Sebastián Lehuedé
doaj   +1 more source