Results 61 to 70 of about 227,255 (301)

Learning about AI ethics from cases: a scoping review of AI incident repositories and cases [PDF]

Cases provide a practical resource for learning regarding the uses and challenges of AI applications. Cases give insight into how principles and values are implicated in real contexts, the trade-offs and different perspectives held regarding these ...
Knight, Simon, McGrath, Cormac, Pargman, TC, Viberg, O, McGrath, C, Viberg, Olga, Knight, S, Cerratto-Pargman, Teresa   +7 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Ethical AI governance: Mapping a Research Ecosystem [PDF]

How do we assess the positive and negative impacts of research about- or research that employs artificial intelligence (AI), and how adequate are existing research governance frameworks for these ends?
Shibani, A, Vincent, N, Knight, S
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The Double Helix of Data Extraction

Technology and Regulation
The increasing value of data is rendering data extraction ubiquitous. Looking at recent research, I argue that work critical of extractive dynamics can give rise to a ‘double-helix of data extraction’ that exacerbates existing asymmetries by ...
Sebastián Lehuedé
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Que(e)rying artificial intelligence use for infectious disease surveillance: The need for a reparative algorithmic praxis

Big Data & Society
The increasing likelihood of pandemics highlights the need for superior tools at our disposal. By robustly and efficiently analyzing vast datasets, artificial intelligence (AI) has the potential to help decision-makers better respond to, manage, and even
Elise E. Racine
doaj   +1 more source

Should we communicate with the dead to assuage our grief? An Ubuntu perspective on using griefbots

Data & Policy
During the 20th century, dealing with grief through an ongoing involvement with the deceased (such as speaking to their grave) was seen as pathological by Western authors such as Sigmund Freud.
Connor Wright
doaj   +1 more source