Results 121 to 130 of about 299,745 (294)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial. [PDF]

, 2019
BackgroundWe describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC).ObjectiveTo describe the feasibility and effectiveness of an acupressure ...
Adcock, Robyn, Banerjee, Anu, Dvorak, Christopher C, Golden, Carla, Hartogensis, Wendy, Hecht, Frederick M, Hu, Hiroe, Lown, E Anne, Mangurian, Christina, Melton, Alexis, Morgan, Michael, Shear, Deborah, Vittinghoff, Eric   +12 more
core   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

The influence of generative artificial intelligence on creative cognition of design students: a chain mediation model of self-efficacy and anxiety

Frontiers in Psychology
IntroductionThis study investigated the role of generative Artificial Intelligence (AI) in enhancing the creative cognition of design students, examining the mediating effects of self-efficacy and anxiety reduction.MethodsA quantitative approach was ...
Younjung Hwang, Yi Wu
doaj   +1 more source

Usage of AI Based ChatGPT, Students’ Self Efficacy and Engagement in Mathematics

Asian Research Journal of Arts & Social Sciences
This quantitative, descriptive-correlational study explores the relationship between the usage of AI-based ChatGPT and students’ self-efficacy and engagement in mathematics learning at Mt. Apo National High School. Standardized and validated survey instruments measured students’ perceived usage of ChatGPT, mathematical self-efficacy, and engagement ...
Medrano, Greatchen L, Engi, Sheilla May S, Yurango, Carlito P   +2 more
openaire   +2 more sources

MicrobeDiscover: A Knowledge Graph–Enabled AI Framework for Identifying Microbes for Inorganic Nanomaterial Biosynthesis

Advanced Science, EarlyView.
Microbial synthesis of nanomaterials (NMs) is eco‐friendly, but the screening of microorganisms is limited by inefficient traditional methods (currently only involving∽400 microorganisms/90 NMs). We propose AI framework MicrobeDiscover, integrating a knowledge graph of microbe‐NM interactions.
Ludi Wang, Hexing Han, Yufeng Liu, Zhiyuan Ning, Yujie Ma, Haidan Wang, Jinling Xu, Qiansheng Huang, Wenjuan Cui, Yuanchun Zhou, Yang Gao, Bin Wang, Yi Du   +12 more
wiley   +1 more source

Artificial Intelligence Perceptions and Technostress in Staff Radiologists: The Mediating Role of Artificial Intelligence Acceptance and the Moderating Role of Self-Efficacy

Behavioral Sciences
This study examined how perceptions of artificial intelligence (AI) relate to technostress in healthcare professionals, testing whether AI acceptance mediates this relationship and whether self-efficacy moderates the formation of acceptance.
Giovanni Di Stefano, Sergio Salerno, Domenica Matranga, Manuela Lodico, Dario Monzani, Valeria Seidita, Roberto Cannella, Laura Maniscalco, Silvana Miceli   +8 more
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Comparing The Effects Of Menthol Status On The Behavioral Pharmacology Of Smoking Reduced Nicotine Content Cigarettes [PDF]

, 2017
Introduction: An active area of tobacco regulatory science research focuses on examining the effects of varying the nicotine content of cigarettes as part of a potential national policy to lower their nicotine content levels to reduce addiction potential.
Davis, Danielle
core   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source