Results 211 to 220 of about 2,400,430 (354)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Before and After Covid-19: What Has Changed in HIV Knowledge Level?

Journal of Multidisciplinary Healthcare
Semiha Çelik Ekinci,1 Kazım Kıratlı2 1University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey; 2Katip Celebi University, Ataturk
Çelik Ekinci S, Kıratlı K
doaj  

The lung microbiome in patients with HIV complicated with community-acquired pneumonia: a cross-sectional pilot study. [PDF]

Curr Res Microb Sci
Song Y, Xu X, Xie M, Tao J, Jin H, Liu Y, Liu L, Song X, Meng S, Cheong IH, Wang Y, Wei Q.   +11 more
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Development and validation of the AIDS scale among the system of quality of life instruments for chronic diseases (QLICD-HIV V2.0). [PDF]

BMC Infect Dis
Sun X, Qiao L, Ding H, Jiang J, Chen Y, Wan C.   +5 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Stakeholders' perspectives on funding malaria, HIV/AIDS and tuberculosis services in Tanzania through domestic resources mobilisation: a qualitative study. [PDF]

BMJ Public Health
Ngadaya FD, Isangula K, Kimambo H, Soka G, Kitinya C, Philbert D, Mwenda L, Kagaruki GB, Kimaro G, Ngadaya E, Kahwa A, Mfinanga S.   +11 more
europepmc   +1 more source

AIDS [PDF]

Eye, 1988
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Prevalence and factors associated with high-risk human papillomavirus infection in women living with HIV/AIDS at a referral center: a cross-sectional study, Vitória, 2021-2022. [PDF]

Epidemiol Serv Saude
Rocha WP, Reuter T, Gaspar PC, Leitão FNC, Barille G, Boldrini NAT, Silveira MFD, Miranda AE.   +7 more
europepmc   +1 more source