Results 181 to 190 of about 53,072 (310)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

COVID-19 Vaccination in Adults: Results from the Tanzania HIV Impact Survey 2022-2023. [PDF]

Vaccines (Basel)
Damian DJ, Cosmas SG, Wang A, Kagashe M, Haji A, Rwehumbiza J, Issa F, Khatib A, Karugendo E, Mchau G, Sumba S, Laws R, Mayige M, Schaad N, Kamwela J, Faki F, Kakiziba DM, Moremi N, Swaminathan M, Porter SE, Pendo P.   +20 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Self-administered digital vaccination decision-aids in primary care: A pilot study of COVID-19 vaccination in Atlanta, GA. [PDF]

Digit Health
White J, Shah T, Wall E, Patel SA, Wu K, Shi Y, Zhang Y, Dong Z, Kulshreshtha A.   +8 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Comparison of safety and immunogenicity between high-dose and low-dose quadrivalent influenza vaccines in children aged 6-35 months in China: A randomized, double-blind clinical study. [PDF]

Hum Vaccin Immunother
Guo X, Li J, Dong X, Xing K, Xu X, Xu W, Wang C, Li K, Gao X, Qiu Y, Guo Z, Xu W, Zhao C, Ma Y, Wu Y, Liu X, Li G.   +16 more
europepmc   +1 more source

The Importance of Pediatric Nonhuman Primate Models in Translational HIV Research. [PDF]

J Med Primatol
Chahroudi A.
europepmc   +1 more source

Demanding solidarity, not salvation: sex work and global health. [PDF]

BMJ Glob Health
Richter ML, Ditmore MH, de Vries J.
europepmc   +1 more source

Japanese Encephalitis Vaccine Decision Aid for Travelers: A Randomized Clinical Trial.

JAMA Netw Open
McGuinness SL, Eades O, Morris J, Seale H, Cheng AC, Leder K.   +5 more
europepmc   +1 more source

Challenges in the Vaccination of HIV-Infected Individuals. [PDF]

Vaccines (Basel)
Sisteré-Oró M, Güerri-Fernandez R, Plana M, Bocharov G, Meyerhans A.   +4 more
europepmc   +1 more source