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Immunology and the elusive AIDS vaccine
Nature, 2010Developing a human immunodeficiency virus (HIV) vaccine is critical to end the global acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this goal is achievable. Natural immunity is not protective, and despite immunogenicity of HIV vaccine candidates, human trials have exclusively yielded disappointing results.
Herbert W, Virgin, Bruce D, Walker
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Inching towards a vaccine for AIDS
Current Biology, 1992Abstract Tests in animal models are confirming suspicions that an effective, prophylactic vaccine against AIDS will be difficult to develop.
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AIDS vaccines and adjuvant formulations
International Journal of Immunopharmacology, 1994The AIDS epidemic is too large to continue ignoring prevention programs that appear to work. In this review the promising experimental immunogens and how close they are to the optimal requirements for a preventive vaccine are presented. Adjuvants and adjuvant formulations (mainly mixtures of adjuvants with suitable vehicles) can help in solving some ...
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AIDS vaccine research in the UK
Vaccine, 1990The UK Medical Research Council initiated a Directed Programme, aimed at developing vaccines for prevention and drugs for treatment of HIV infection and AIDS, in April 1987. This is a single collaborative research programme encompassing work in about 100 UK laboratories together with a small number in Europe and the USA.
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