Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1 [PDF]
Scientific ReportsThe inflammatory corpuscle recombinant absents in melanoma 2 (AIM2) and cholesterol efflux protein ATP binding cassette transporter A1(ABCA1) have been reported to play opposing roles in atherosclerosis (AS) plaques.
Shujiang Zhuo +6 more
doaj +3 more sources
SIK2 mediated mitochondrial homeostasis in spinal cord injury: modulating oxidative stress and the AIM2 inflammasome via CRTC1/CREB signaling. [PDF]
J NeuroinflammationMitochondrial oxidative stress and the absent in melanoma 2 (AIM2) inflammasome play crucial roles in the regulation of secondary injury in patients with spinal cord injury (SCI).
Fang N +9 more
europepmc +2 more sources
The role of AIM2 inflammasome pathway-mediated pyroptosis on brain injury induced by severe acute pancreatitis in mice [PDF]
Scientific ReportsThis study aimed to investigate the role of the AIM2 inflammasome pathway-mediated pyroptosis in severe acute pancreatitis-induced brain injury (SAP-IBI) utilizing a murine model. A male C57BL/6 murine model of SAP-IBI was established.
Xiaohong Wang +6 more
doaj +2 more sources
AIM2 drives inflammatory cell death and monkeypox pathogenesis. [PDF]
Cell Mol ImmunolMonkeypox, a zoonotic disease caused by the monkeypox virus (MPXV), has significant global public health implications. Inflammasomes serve as crucial components of the innate immune system, detecting pathogens and triggering cell death in infected cells ...
Oh J +20 more
europepmc +2 more sources
Assembly mechanism of the inflammasome sensor AIM2 revealed by single molecule analysis [PDF]
Nature Communications, 2023 Pathogenic dsDNA prompts AIM2 assembly leading to the formation of the inflammasome, a multimeric complex that triggers the inflammatory response. The recognition of foreign dsDNA involves AIM2 self-assembly concomitant with dsDNA binding.
Meenakshi Sharma, Eva de Alba
doaj +2 more sources
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication. [PDF]
PLoS PathogensThe absent in melanoma 2 (AIM2) protein recognizes viral and naked dsDNA and recruit apoptosis-associated speck-like protein containing CARD (ASC) to initiate inflammasome activation; however, the subversion of AIM2 activation by Epstein-Barr virus (EBV)
Qingping Lan +5 more
doaj +2 more sources
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury
Cell Death DiscoveryThe cytoplasmic pattern recognition receptor, absent in melanoma 2 (AIM2), detects cytosolic DNA, activating the inflammasome and resulting in pro-inflammatory cytokine production and pyroptotic cell death.
Chao Hu +13 more
doaj +2 more sources
The DNA sensor AIM2 mediates psoriasiform inflammation by inducing type 3 immunity [PDF]
JCI InsightPsoriasis is a chronic and recurrent inflammatory skin disease characterized by abnormal proliferation and differentiation of keratinocytes and activation of immune cells. However, the molecular driver that triggers this immune response in psoriatic skin
Timna Varela Martins +14 more
openalex +2 more sources
Epigenetics & ChromatinBackground The development of breast cancer is known to be greatly influenced by epigenetic changes. The impact of histone acetyltransferase KAT2B on AIM2 and AKT/Wnt/β-catenin signaling have not been studied yet.
Yaqiong Li +5 more
doaj +2 more sources
Role of the AIM2 Inflammasome in Cancer: Potential Therapeutic Strategies
BiomedicinesAbsent in melanoma 2 (AIM2) is a member of the innate immune sensors that recognizes cytosolic nucleic acids, leading to inflammasome assembly. In recent years, several studies in the oncology field have highlighted the presence of cytoplasmic double ...
Chiara Colarusso +6 more
doaj +2 more sources