The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]
Nature Immunology, 2010 Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S +12 more
core +13 more sources
Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis
Frontiers in Genetics, 2022 Psoriasis is an immune-mediated chronic inflammatory skin disease caused by a combination of environmental incentives, polygenic genetic control, and immune regulation.
Jieyi Wang +21 more
doaj +4 more sources
Role of the AIM2 Inflammasome in Cancer: Potential Therapeutic Strategies [PDF]
BiomedicinesAbsent in melanoma 2 (AIM2) is a member of the innate immune sensors that recognizes cytosolic nucleic acids, leading to inflammasome assembly. In recent years, several studies in the oncology field have highlighted the presence of cytoplasmic double ...
Chiara Colarusso +6 more
doaj +4 more sources
The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication. [PDF]
PLoS PathogensThe absent in melanoma 2 (AIM2) protein recognizes viral and naked dsDNA and recruit apoptosis-associated speck-like protein containing CARD (ASC) to initiate inflammasome activation; however, the subversion of AIM2 activation by Epstein-Barr virus (EBV)
Qingping Lan +5 more
doaj +2 more sources
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury [PDF]
, 2018 Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues containing actively proliferating cells, including bone marrow and the gastrointestinal tract.
Cetinbas, Naniye +15 more
core +2 more sources
Characterization of AIM2 DNA-Binding Properties and Filament Formation [PDF]
, 2008 High levels of thrombin-activatable fibrinolysis inhibitor (TAFI) are a supposed risk factor for thrombosis. However, results from previous studies are conflicting.We assessed the absolute risk of venous and arterial thromboembolism in subjects with high
Bom, Victor J. J. +8 more
core +4 more sources
Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression [PDF]
Epigenetics & ChromatinBackground The development of breast cancer is known to be greatly influenced by epigenetic changes. The impact of histone acetyltransferase KAT2B on AIM2 and AKT/Wnt/β-catenin signaling have not been studied yet.
Yaqiong Li +4 more
doaj +2 more sources
AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma
Frontiers in Pharmacology, 2022 A large proportion of bladder cancer (BLCA) patients suffer from malignant progression to life-threatening muscle-invasive bladder cancer (MIBC). Inflammation is a critical event in cancer development, but little is known about the role of inflammation ...
Houhong Zhou +10 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2023 This work was devised to discuss the effect of AIM2 on the immunosuppression of LUAD tumors, as well as its molecular mechanism. An allograft mouse model was built. Mouse macrophages were isolated and collected.
Hua Ye +9 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was
Yan Qin +8 more
doaj +1 more source