Results 91 to 100 of about 22,661 (290)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease

Clinical and Translational Medicine, 2022
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that involves T follicular helper (TFH) cell‐mediated humoral immune responses. Absent in melanoma 2 (human AIM2 and murine Aim2) is a well‐known component of the inflammasome in the ...
Haijing Wu, Yaxiong Deng, Di Long, Ming Yang, Qianwen Li, Yu Feng, Yongjian Chen, Hong Qiu, Xin Huang, Zhenghao He, Longyuan Hu, Heng Yin, Guangdi Li, Yunkai Guo, Wenhan Du, Ming Zhao, Liwei Lu, Qianjin Lu   +17 more
doaj   +1 more source

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly [PDF]

, 2016
Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. This leads to secretion of proinflammatory cytokines and pyroptosis.
Adams, Aida, Alvin Lu, Antonin, Arora, Ashour, Barrios-Rodiles, Broz, Broz, Burg, Cai, Catherine Tang, Chakrabarti, Chen, Conrath, de Alba, Delaloye, Doxsey, Emsley, Fernandes-Alnemri, Ferrao, Florian I. Schmidt, Guimaraes, Hamers-Casterman, Hao Wu, Hauenstein, Helma, Hidde L. Ploegh, Hornung, Hu, Irannejad, Jakobs, Jeff W. Chen, Jianbin Ruan, Kagan, Kirchhofer, Kortmann, Lechtenberg, Lin, Lu, Maass, Man, Masumoto, Masumoto, Meerbrey, Milne, Muyldermans, Paalanen, Pardon, Sahillioglu, Sborgi, Shenoy, Sosa, Taipale, Vanaja, Vance, Wu, Wu, Yang, Young, Zhang   +60 more
core   +1 more source

The AIM2 inflammasome is activated in astrocytes during the late phase of EAE [PDF]

, 2022
William E. Barclay, Nupur Aggarwal, M. Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Edward A. Miao, Mari L. Shinohara   +8 more
openalex   +1 more source

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2014
The central nervous system (CNS) is an active participant in the innate immune response to infection and injury. In these studies, we show embryonic cortical neurons express a functional, deoxyribonucleic acid (DNA)-responsive, absent in melanoma 2 (AIM2) inflammasome that activates caspase-1.
Stephanie E, Adamczak, Juan Pablo, de Rivero Vaccari, Gordon, Dale, Frank J, Brand, Doris, Nonner, M Ross, Bullock, Gerhard P, Dahl, W Dalton, Dietrich, Robert W, Keane   +8 more
openaire   +2 more sources

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources

Identification of Aim2 as a Sensor for DNA Vaccines [PDF]

The Journal of Immunology, 2015
Abstract Recent human study data have re-established the value of DNA vaccines, especially in priming high-level Ag-specific Ab responses, but also raised questions about the mechanisms responsible for such effects. Whereas previous reports have shown involvement of downstream signaling molecules in the innate immune system, the current ...
Suschak, John, Wang, Shixia, Fitzgerald, Katherine A, Lu, Shan   +3 more
openaire   +3 more sources

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, EarlyView.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Characterization of AIM2 DNA-Binding Properties and Filament Formation [PDF]

, 2008
High levels of thrombin-activatable fibrinolysis inhibitor (TAFI) are a supposed risk factor for thrombosis. However, results from previous studies are conflicting.We assessed the absolute risk of venous and arterial thromboembolism in subjects with high
Bom, Victor J. J., Buller, Harry R., Coppens, Michiel, Folkeringa, Nienke, Hamulyak, Karly, Middeldorp, Saskia, Prins, Martin H., van der Meer, Jan, Veeger, Nic J. G. M.   +8 more
core   +2 more sources