Results 101 to 110 of about 19,682 (247)

AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

Journal of Inflammation, 2021
Introduction The role inflammasomes play in chronic obstructive pulmonary disease (COPD) is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of COPD patients, and in response to cigarette smoke.
Hai B. Tran, Rhys Hamon, Hubertus Jersmann, Miranda P. Ween, Patrick Asare, Rainer Haberberger, Harshita Pant, Sandra J. Hodge   +7 more
doaj   +1 more source

A Machine Learning‐Optimized Immunogenic Cell Death Signature Reveals Tumor Immunogenicity and the Immunotherapy Response of Pancancer

MedComm – Future Medicine, Volume 4, Issue 4, December 2025.
This study introduces an innovative adversarial validation (AV) strategy integrated with machine learning to mitigate the problem of data set shift and enhance analyses of pan‐cancer immunogenicity. It identifies key immunogenic cell death‐related biomarkers and demonstrates their predictive potential for survival outcomes and responses to PD‐1 ...
Li Qiu, Danqing Huang, Yuening Zhang, Yingying Zhou, Ming Luo, Chengdong Zhang, Ying Huang, Mingyuan Zou, Wenlong Lu, Hui Liu, Shaowei Liu, Haoyang Huang, Kaiwen Ye, Yuan Hui, Cheng Tang, Zilong Yan, Xi Zhong, Zhiguo Luo, Hongxin Huang, Ming Zhou, Guangshuai Jia, Qibin Leng, Jun Liu   +22 more
wiley   +1 more source

An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models [PDF]

, 2016
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with aggregation of TAR DNA-binding protein-43 (TDP-43) in neuronal cells and manifests as motor neuron dysfunction & muscle atrophy.
G, Prabusankar, Girdhar, A, Patel, Basant Kumar, Prasad, A, Raju, G, Sivalingam, V, Taneja, V, Vats, A, Verma, M   +8 more
core   +1 more source

Separase Inhibition Enhances Gefitinib Sensitivity of Lung Cancer via PTBP1/TAK1/RIPK1‐Mediated PANoptosis

MedComm, Volume 6, Issue 11, November 2025.
Inhibiting separase with the specific inhibitor Sepin‐1 has been found to effectively enhance gefitinib‐induced cytotoxic in lung cancer cell. Mechanically, separase inhibitor Sepin‐1 plus gefitinib decreases the expression of PTBP1 and TAK1 to trigger RIPK1‐dependent PANoptosis. ABSTRACT Gefitinib is the most frequently employed anti‐lung cancer drug,
Zhouyangfan Peng, Liangpeng Xie, Sufang Zhou, Yapei Li   +3 more
wiley   +1 more source

Impact of NLRP1 Met1154Val and IL1B variants on gestational malaria: an unexplored role of NLRP1 in inflammasome activation by Plasmodium spp.

The Journal of Pathology, Volume 267, Issue 3, Page 304-314, November 2025.
Abstract We hypothesized that variants in inflammasome‐related genes could influence susceptibility to gestational malaria (GM). To test this, we conducted an association study in a cohort of pregnant women from a malaria‐endemic region in northern Brazil, assessing whether specific functional single nucleotide variants (SNVs) in inflammasome genes ...
Vinicius NC Leal, Jessica A Ribeiro, Leticia Girardi Marra, Alexandre TT Rio, Edione C Reis, Gerhard Wunderlich, Jamille G Dombrowski, Claudio RF Marinho, Alessandra Pontillo   +8 more
wiley   +1 more source

AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury

Cell Death Discovery
The cytoplasmic pattern recognition receptor, absent in melanoma 2 (AIM2), detects cytosolic DNA, activating the inflammasome and resulting in pro-inflammatory cytokine production and pyroptotic cell death.
Chao Hu, Mengjing Li, Yongzhen Chen, Wei Cheng, Haining Wang, Yiming Zhou, Fengmeng Teng, Tao Ling, Jinshun Pan, Haozhe Xu, Yanan Zheng, Guozhong Ji, Ting Zhao, Qiang You   +13 more
doaj   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1

Scientific Reports
The inflammatory corpuscle recombinant absents in melanoma 2 (AIM2) and cholesterol efflux protein ATP binding cassette transporter A1(ABCA1) have been reported to play opposing roles in atherosclerosis (AS) plaques.
Shujiang Zhuo, Sufei Song, Chaoyi Wang, Zhe Wang, Ming Zhang, Daobin Lin, Kaili Chen   +6 more
doaj   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Viral modulation of interferon (IFN) responses to african swine fever virus (ASFV) [PDF]

, 2011
Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2011A imunidade inata constitui a primeira resposta dada por um hospedeiro quando atacado por agentes patogénicos. A resposta imune baseia-se em genes
Costa, Emanuel Nery de Oliveira Quartin, 1986-
core