Results 111 to 120 of about 19,682 (247)

OM-85 is an immunomodulator of interferon-β production and inflammasome activity. [PDF]

, 2017
The inflammasome-IL-1 axis and type I interferons (IFNs) have been shown to exert protective effects upon respiratory tract infections. Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive ...
Dang, A.T., Guarda, G., Ludigs, K., Pasquali, C.   +3 more
core   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, Volume 47, Issue 10, October 2025.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

Usability of serum AIM2 as a predictive biomarker of stroke-associated pneumonia and poor prognosis after acute supratentorial intracerebral hemorrhage: A prospective longitudinal cohort study

Heliyon
Background: Absent in melanoma 2 (AIM2) is implicated in inflammatory processes. We measured serum AIM2 with intent to unveil its predictive significance for stroke-associated pneumonia (SAP) and functional prognosis following acute intracerebral ...
Chengliang Zhang, Chuanliu Wang, Ming Yang, Han Wen, Ping Li   +4 more
doaj   +1 more source

Novel role of PKR in inflammasome activation and HMGB1 release [PDF]

, 2014
The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an important role of double-stranded RNA
Andersson, Ulf, Antoine, Daniel J., Chavan, Sangeeta S., Erlandsson-Harris, Helena, Hotamisligil, Gökhan S., Inouye, Karen, Kalb, Thomas, Li, Jianhua, Lu, Ben, Lundbäck, Peter, Nakamura, Takahisa, Olofsson, Peder S., Roth, Jesse, Tang, Yiting, Ting, Jenny P-Y, Tracey, Kevin J., Valdes-Ferrer, Sergio I, Wang, Haichao, Yang, Huan, Zou, Yongrui   +19 more
core   +1 more source

STING inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis

The Journal of Pathology, Volume 267, Issue 2, Page 196-212, October 2025.
Abstract Peritoneal dialysis (PD) is a widely used kidney replacement therapy for patients with end‐stage kidney disease. Nevertheless, long‐term exposure to PD fluid can damage the peritoneal membrane, leading to ultrafiltration failure and, ultimately, discontinuation of PD.
Vanessa Marchant, Jorge García‐Giménez, Guadalupe T González‐Mateo, Pilar Sandoval, Lucía Tejedor‐Santamaria, Sandra Rayego‐Mateos, Ricardo Ramos, José A Jiménez‐Heffernan, Alberto Ortiz, Anne‐Catherine Raby, Manuel López‐Cabrera, Adrián M Ramos, Marta Ruiz‐Ortega   +12 more
wiley   +1 more source

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90366/1/j.1365-2249.2011.04535.x ...
Franchi, Luigi, Ozkurede, V. U.
core   +1 more source

The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Andrographolide, a diterpenoid component found in traditional Chinese medicine Andrographis paniculata, is known as a natural antibiotic and can be used to treat inflammatory lesions of various systemic diseases. In recent years, andrographolide derivatives have been continuously synthesized and have shown good anti‐inflammatory ...
Xiaoqin Shan, Siyi Li, Jiayi Liu, Can Wang, Yao Wei, Jiayi Shi, Xinyue Zhang, Lili Gu   +7 more
wiley   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

British Journal of Pharmacology, Volume 182, Issue 20, Page 4876-4893, October 2025.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding, Chengqing Ning, Shao‐Ru Chen, Hao‐Ran Yin, Jing Xu, Ying Wang   +5 more
wiley   +1 more source

Taking AIM at Influenza: The Role of the AIM2 Inflammasome

Viruses
Influenza A viruses (IAV) are dynamic and highly mutable respiratory pathogens that present persistent public health challenges. Inflammasomes, as components of the innate immune system, play a crucial role in the early detection and response to infections. They react to viral pathogens by triggering inflammation to promote immune defences and initiate
Dianne W. Xu, Michelle D. Tate
openaire   +3 more sources

A High-Protein Diet Promotes Atrial Arrhythmogenesis via Absent-in-Melanoma 2 Inflammasome

Cells
High-protein diets (HPDs) offer health benefits, such as weight management and improved metabolic profiles. The effects of HPD on cardiac arrhythmogenesis remain unclear.
Jia Song, Jiao Wu, Dexter J. Robichaux, Tingting Li, Shuyue Wang, Maria J. Arredondo Sancristobal, Bingning Dong, Dobromir Dobrev, Jason Karch, Sandhya S. Thomas, Na Li   +10 more
doaj   +1 more source