Results 131 to 140 of about 19,682 (247)

Hematopoietic interferon-inducible nuclear proteins with a 200-amino-acid repeat (HIN-200) gene family; tumor protein p53 binding protein 1 (TP53BP1; p202); absent in melanoma 2 (AIM2; p210) [PDF]

, 2009

openalex   +1 more source

The Role of AIM2 in Cancer Development: Inflammasomes and Beyond

Journal of Cancer
Absence in melanoma 2 (AIM2) protein functions as a double-stranded DNA sensor and is critical for host defense against intracellular bacterial and viral pathogens. Recent research has highlighted the significance of AIM2 in the pathogenesis of diverse malignancies.
Sui, Lina, Xi, Yuling, Zheng, Siping, Xiao, Qiuxiang, Liu, Zhiping   +4 more
openaire   +2 more sources

Crystallographic characterization of mouse AIM2 HIN-200 domain bound to a 15 bp and an 18 bp double-stranded DNA [PDF]

, 2012
Min Woo Sung, Tylan Watts, Pingwei Li
openalex   +1 more source

A computationally efficient inorganic atmospheric aerosol phase equilibrium model (UHAERO) [PDF]

, 2005
A variety of thermodynamic models have been developed to predict inorganic gas-aerosol equilibrium. To achieve computational efficiency a number of the models rely on a priori specification of the phases present in certain relative humidity regimes ...
Amundson, N. R., Caboussat, A., He, J. W., Martynenko, A. V., Savarin, V. B., Seinfeld, J. H., Yoo, K. Y.   +6 more
core   +1 more source

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC [PDF]

, 2013
Vitaliya Sagulenko, Sara J Thygesen, David P. Sester, Adi Idris, Jasmyn A. Cridland, Parimala R. Vajjhala, Tara L. Roberts, Kate Schroder, James E. Vince, Jennifer M. Hill, John Silke, Katryn J. Stacey   +11 more
openalex   +1 more source

Hepatocellular carcinoma and AIM2: Therapeutic potential through regulation of autophagy and macrophage polarization

Immunity, Inflammation and Disease
Objective Hepatocellular carcinoma (HCC) poses a significant challenge to global health. Its pathophysiology involves interconnected processes, including cell proliferation, autophagy, and macrophage polarization.
Shuangshuang Xie, Cuiyun Wang, Xiaoyan Liu, Cheng Li, Jinhong Yu, Shumin Ma, Qiang Li, Wenjun Du   +7 more
doaj   +1 more source

Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]

, 2015
Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core   +1 more source

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation [PDF]

, 2013
Qian Yin, David P. Sester, Yuan Tian, Yu‐Shan Hsiao, Alvin Lu, Jasmyn A. Cridland, Vitaliya Sagulenko, Sara J Thygesen, Divaker Choubey, Veit Hornung, Thomas Walz, Katryn J. Stacey, Hao Wu   +12 more
openalex   +1 more source

Identificación de nuevos agentes reguladores del inflamasoma: posibilidades para el desarrollo de fármacos antiinflamatorios [PDF]

, 2018
El contenido de esta revisión parte de un conocimiento global sobre el inflamasoma. Comenzando por los receptores de reconocimiento de patrones o PRR, que pueden tener una localización transmembranal o bien en orgánulos intracelulares.
Martín Marín, Lara
core  

AIM2 inflammasome regulated by the IFN‐γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease

Immunity, Inflammation and Disease
Background Numerous studies have demonstrated that Absent in Melanoma 2 (AIM2) is upregulated in aortic plaques, especially in Vascular Smooth Muscle Cells in Coronary Artery Disease (CAD), and is related to inflammasome‐induced inflammation.
Yue Zhao, Bin Liang, Shuyang Sheng, Chen Wang, Bingyu Jin, Xiaokang Zhang, Yating Cheng, Changxin Shen, Fang Zheng   +8 more
doaj   +1 more source