Results 11 to 20 of about 19,682 (247)
TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy [PDF]
Cell Reports, 2016 The AIM2 inflammasome is a key cytosolic signaling complex that is activated by double-stranded DNA, leading to the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18.
Tao Liu +7 more
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The complex role of AIM2 in autoimmune diseases and cancers [PDF]
Immunity, Inflammation and Disease, 2021 Absent in melanoma 2 (AIM2) is a novel member of interferon (IFN)‐inducible PYHIN proteins. In innate immune cells, AIM2 servers as a cytoplasmic double‐stranded DNA sensor, playing a crucial role in the initiation of the innate immune response as a ...
Huan Zhu +5 more
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Maturation-dependent expression of AIM2 in human B-cells. [PDF]
PLoS ONE, 2017 Intracellular DNA- and RNA-sensing receptors, such as the IFN-inducible protein Absent in Melanoma 2 (AIM2), serve as host sensors against a wide range of infections.
Alexandra Svensson +4 more
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The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications
Frontiers in ImmunologyAIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of activation, emphasizing its capacity to detect cytosolic DNA and initiate ...
Kai Yang +10 more
doaj +3 more sources
Identification of AIM2 as a downstream target of JAK2V617F [PDF]
Experimental Hematology & Oncology, 2015 The gain-of-function mutation JAK2V617F is frequently found in Philadelphia-chromosome-negative myeloproliferative neoplasm (MPN) patients. However, the tumorigenic properties of JAK2V617F have mostly been characterized in in vivo and in vitro murine models due to the lack of appropriate human cell lines.Using the multipotent hematologic cell line UT-7/
Ei Leen Liew +8 more
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Critical role of AIM2 in Mycobacterium tuberculosis infection [PDF]
International Immunology, 2012 Abstract Abstract Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria. However, the role of AIM2 in host defenses against Mycobacterium tuberculosis is unknown.
Hiroyuki Saiga +7 more
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Inflammasome-independent functions of AIM2 [PDF]
Journal of Experimental Medicine, 2021 AIM2 is widely known for its role as a cytosolic dsDNA receptor that activates the inflammasome. In this issue of JEM, Ma et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201796) describe an inflammasome-independent function of AIM2 in microglia that restrains neuroinflammation via a novel crosstalk between AIM2 and cGAS signaling.
Xiaoxia Li +3 more
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Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome [PDF]
Current Biology, 2009 Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and ...
Kate Schroder +2 more
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The Emerging Relevance of AIM2 in Liver Disease [PDF]
International Journal of Molecular Sciences, 2020 Absent in melanoma 2 (AIM2) is a cytosolic receptor that recognizes double-stranded DNA (dsDNA) and triggers the activation of the inflammasome cascade. Activation of the inflammasome results in the maturation of inflammatory cytokines, such as interleukin (IL)-1 β and IL-18, and a form of cell death known as pyroptosis.
Beatriz Lozano-Ruiz +1 more
openaire +5 more sources
Frontiers in Immunology, 2023 Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic complications, which seriously affect the quality of life and physical and mental health of patients. The pathogenesis of psoriasis is related to the environment, genetics, epigenetics, and dysregulation of immune cells such as T cells, dendritic cells (DCs ...
Yuxi Zhang +15 more
openaire +3 more sources