Results 11 to 20 of about 22,661 (290)

Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis

Frontiers in Genetics, 2022
Psoriasis is an immune-mediated chronic inflammatory skin disease caused by a combination of environmental incentives, polygenic genetic control, and immune regulation.
Jieyi Wang, Jieyi Wang, Jieyi Wang, Jing Gao, Jing Gao, Cong Huang, Cong Huang, Sohyun Jeong, Sohyun Jeong, Randy Ko, Xue Shen, Chaofeng Chen, Chaofeng Chen, Weilong Zhong, Weilong Zhong, Yanfen Zou, Yanfen Zou, Bo Yu, Bo Yu, Bo Yu, Changbing Shen, Changbing Shen   +21 more
doaj   +4 more sources

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy [PDF]

Cell Reports, 2016
The AIM2 inflammasome is a key cytosolic signaling complex that is activated by double-stranded DNA, leading to the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18.
Tao Liu, Qin Tang, Kunpeng Liu, Weihong Xie, Xin Liu, Huishan Wang, Rong-Fu Wang, Jun Cui   +7 more
doaj   +3 more sources

Maturation-dependent expression of AIM2 in human B-cells. [PDF]

PLoS ONE, 2017
Intracellular DNA- and RNA-sensing receptors, such as the IFN-inducible protein Absent in Melanoma 2 (AIM2), serve as host sensors against a wide range of infections.
Alexandra Svensson, Marianela Patzi Churqui, Kerstin Schlüter, Liza Lind, Kristina Eriksson   +4 more
doaj   +5 more sources

Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis

Cell Communication and Signaling
Background Absent in melanoma 2 (AIM2) inflammasome-dependent pyroptosis and neutrophil extracellular traps (NETs) have been implicated in chronic liver disease (CLD).
Yu Zhang, Rong Wu, Xi Zhan, Xuan-Yi Wang, Lin-Wei Xiang, Ya-Qian Duan, Yan You, Jian-Bo Zhang, Rui Wu, Yun-Yuan Zhang, Liang Duan   +10 more
doaj   +2 more sources

AIM2 inflammasome regulated by the IFN‐γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease

Immunity, Inflammation and Disease
Background Numerous studies have demonstrated that Absent in Melanoma 2 (AIM2) is upregulated in aortic plaques, especially in Vascular Smooth Muscle Cells in Coronary Artery Disease (CAD), and is related to inflammasome‐induced inflammation.
Yue Zhao, Bin Liang, Shuyang Sheng, Chen Wang, Bingyu Jin, Xiaokang Zhang, Yating Cheng, Changxin Shen, Fang Zheng   +8 more
doaj   +2 more sources

The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications

Frontiers in Immunology
AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of activation, emphasizing its capacity to detect cytosolic DNA and initiate ...
Kai Yang, Kai Yang, Xi Wang, Hanyu Pan, Xinqing Wang, Yunhan Hu, Yihe Yao, Xinyue Zhao, Taolei Sun, Taolei Sun, Taolei Sun   +10 more
doaj   +2 more sources

NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni [PDF]

bioRxiv
Infection with the helminth Schistosoma mansoni can cause exacerbated morbidity and mortality via a pathogenic host CD4 T cell-mediated immune response directed against parasite egg antigens, with T helper (Th) 17 cells playing a major role in the ...
Madhusoodhanan Suresh Kumar Meena Kumari, Pengyu Liu, Kaile Jump, Yoelkys Morales, Emily Miller, Ilana Shecter, Miguel J. Stadecker, Parisa Kalantari   +7 more
openalex   +2 more sources

Longitudinal change of serum AIM2 levels after aneurysmal subarachnoid hemorrhage and its prognostic significance: a two-center prospective cohort study

Scientific Reports
Absent in melanoma 2 (AIM2) is implicated in neuroinflammation. Here, we explored the prognostic significance of serum AIM2 in human aneurysmal subarachnoid hemorrhage (aSAH).
Ziyin Chen, Shengdong Zou, Hao Shan, Jin Liu, Da Tian, Xiaoyu Wu, Quan Du, Xiaoqiao Dong, Dingbo Yang   +8 more
doaj   +2 more sources

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis [PDF]

Nature, 2021
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells. Clonal haematopoiesis increases the risk of myocardial infarction and stroke independently of traditional risk factors1.
T. Fidler, Chenyi Xue, M. Yalcinkaya, B. Hardaway, Sandra Abramowicz, Tong Xiao, Wenli Liu, D. G. Thomas, M. Hajebrahimi, J. Pircher, C. Silvestre-Roig, Andriana G Kotini, Larry L. Luchsinger, Ying Wei, M. Westerterp, H. Snoeck, E. Papapetrou, C. Schulz, S. Massberg, O. Soehnlein, B. Ebert, R. Levine, M. Reilly, P. Libby, Nan Wang, A. Tall   +25 more
semanticscholar   +3 more sources

New insights into nucleic acid sensor AIM2: The potential benefit in targeted therapy for cancer

Pharmacological Research
The AIM2 inflammasome represents a multifaceted oligomeric protein complex within the innate immune system, with the capacity to perceive double-stranded DNA (dsDNA) and engage in diverse physiological reactions and disease contexts, including cancer ...
Jian-Zhou Cui, Zhi Huan Chew, Lina H.K. Lim   +2 more
doaj   +2 more sources