Results 21 to 30 of about 22,661 (290)
Inflammasome-independent functions of AIM2 [PDF]
Journal of Experimental Medicine, 2021 AIM2 is widely known for its role as a cytosolic dsDNA receptor that activates the inflammasome. In this issue of JEM, Ma et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201796) describe an inflammasome-independent function of AIM2 in microglia that restrains neuroinflammation via a novel crosstalk between AIM2 and cGAS signaling.
Junjie Zhao +2 more
openaire +2 more sources
AIM2-driven inflammasome activation in heart failure [PDF]
Cardiovascular Research, 2021 Abstract Aims Interleukin-1β (IL-1β) is an important pathogenic factor in cardiovascular diseases including chronic heart failure (HF). The CANTOS trial highlighted that inflammasomes as primary sources of IL-1 β are promising new therapeutic targets in cardiovascular diseases.
Zsófia Onódi +19 more
openaire +3 more sources
Frontiers in Immunology, 2023 Psoriasis is a chronic inflammatory skin disease occurring worldwide, with multiple systemic complications, which seriously affect the quality of life and physical and mental health of patients. The pathogenesis of psoriasis is related to the environment, genetics, epigenetics, and dysregulation of immune cells such as T cells, dendritic cells (DCs ...
Yuxi Zhang +15 more
openaire +3 more sources
AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense
Nature, 2021 Inflammasomes are important sentinels of innate immune defence, sensing pathogens and inducing cell death in infected cells1. There are several inflammasome sensors that each detect and respond to a specific pathogen- or damage-associated molecular ...
Sangjoon Lee +5 more
semanticscholar +1 more source
AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma
Frontiers in Pharmacology, 2022 A large proportion of bladder cancer (BLCA) patients suffer from malignant progression to life-threatening muscle-invasive bladder cancer (MIBC). Inflammation is a critical event in cancer development, but little is known about the role of inflammation ...
Houhong Zhou +10 more
doaj +1 more source
Journal of the American Society of Nephrology, 2018 The AIM2 inflammasome senses DNA released by necrotic renal cells and translates a deadly signal into a proinflammatory trigger, thereby providing a prototype example of necroinflammation. Loss of cellular membrane integrity (necrosis) represents a genetically determined and highly regulated ...
Andreas, Linkermann +2 more
openaire +2 more sources
Human Vaccines & Immunotherapeutics, 2023 This work was devised to discuss the effect of AIM2 on the immunosuppression of LUAD tumors, as well as its molecular mechanism. An allograft mouse model was built. Mouse macrophages were isolated and collected.
Hua Ye +9 more
doaj +1 more source
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]
, 2010 Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S +12 more
core +6 more sources
Signal Transduction and Targeted Therapy, 2021 Absent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher AIM2 expression is observed in the B cells from lupus patients.
Ming Yang +12 more
doaj +1 more source
The complex role of AIM2 in autoimmune diseases and cancers
Immunity, Inflammation and Disease, 2021 Absent in melanoma 2 (AIM2) is a novel member of interferon (IFN)‐inducible PYHIN proteins. In innate immune cells, AIM2 servers as a cytoplasmic double‐stranded DNA sensor, playing a crucial role in the initiation of the innate immune response as a ...
Huan Zhu +5 more
doaj +1 more source