Results 21 to 30 of about 19,682 (247)
AIM2-driven inflammasome activation in heart failure [PDF]
Cardiovascular Research, 2021 Abstract Aims Interleukin-1β (IL-1β) is an important pathogenic factor in cardiovascular diseases including chronic heart failure (HF). The CANTOS trial highlighted that inflammasomes as primary sources of IL-1 β are promising new therapeutic targets in cardiovascular diseases.
Zsófia Onódi +19 more
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Journal of the American Society of Nephrology, 2018 The AIM2 inflammasome senses DNA released by necrotic renal cells and translates a deadly signal into a proinflammatory trigger, thereby providing a prototype example of necroinflammation. Loss of cellular membrane integrity (necrosis) represents a genetically determined and highly regulated ...
Andreas Linkermann +2 more
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Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome [PDF]
Virology Journal, 2017 AIM2, a cytosolic DNA sensor, plays an important role during infection caused by pathogens with double-stranded DNA; however, its role in human cytomegalovirus (HCMV) infection remains unclear. Previously, we showed an increase in AIM2 protein levels during the early stage of HCMV infection and a decrease 24 h post infection. Because HCMV has developed
Yi Liao +7 more
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The Role of AIM2 Inflammasome in Knee Osteoarthritis
Journal of Inflammation Research, 2022 Knee osteoarthritis (KOA), whose prevalence keeps rising, is still unsolved pathobiological/therapeutical problem. Historically, knee osteoarthritis was thought to be a "wear and tear" disease, while recent etiology hypotheses stressed it as a chronic, low-grade inflammatory disease.
Jiyong Yang, Wengang Liu
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Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes [PDF]
International Journal of Molecular Sciences, 2021 The inflammasome is a three-component (sensor, adaptor, and effector) filamentous signaling platform that shields from multiple pathogenic infections by stimulating the proteolytical maturation of proinflammatory cytokines and pyroptotic cell death.
Eva de Alba, Meenakshi Sharma
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Signal Transduction and Targeted Therapy, 2021 Absent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes in innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher AIM2 expression is observed in the B cells from lupus patients.
Ming Yang +12 more
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The diagnostic role of AIM2 in Kawasaki disease [PDF]
Clinical and Experimental Medicine, 2020 Kawasaki disease (KD), a systemic vasculitis in children, may bring serious complications. However, the etiology of KD remains unclear. AIM2, an intracellular receptor, plays a vital role during the infection caused by a variety of pathogens. However, its role in KD remains unclear.
Zhenquan Wang +6 more
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The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis [PDF]
Nature, 2021 Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells. Clonal haematopoiesis increases the risk of myocardial infarction and stroke independently of traditional risk factors1.
Nan Wang +28 more
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Identification of Aim2 as a Sensor for DNA Vaccines [PDF]
The Journal of Immunology, 2015 Abstract Recent human study data have re-established the value of DNA vaccines, especially in priming high-level Ag-specific Ab responses, but also raised questions about the mechanisms responsible for such effects. Whereas previous reports have shown involvement of downstream signaling molecules in the innate immune system, the current ...
Suschak, John +3 more
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Scientific Reports, 2021 Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide, and poses a great threat to public health. Absent in melanoma 2 (AIM2), a member of the pyrin-HIN family proteins, plays various roles across different types of cancers.
Dong Wang +3 more
doaj +1 more source