Results 31 to 40 of about 19,682 (247)
AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner
Frontiers in Cell and Developmental Biology, 2021 Absent in melanoma 2 (AIM2), a DNA sensor that plays an important role in natural immunity system, has been reported to participate in colorectal cancer (CRC) development. However, the functional role of AIM2 in BRAF-mutant CRC remains unclear.
Shailendra Shah +8 more
doaj +1 more source
Cells, 2023 Clinical islet transplantation is limited by ischemia-induced islet cell death. Recently, it has been reported that the absent in melanoma (AIM)2 inflammasome is upregulated by ischemic cell death due to recognition of aberrant cytoplasmic self-dsDNA ...
Selina Wrublewsky +5 more
doaj +1 more source
AIM2 Joins the Gang of Microbial Sensors [PDF]
Cell Host & Microbe, 2010 AIM2 was recently implicated in the assembly and activation of the inflammasome in response to eukaryotic and viral dsDNA. Sauer and colleagues (2010) demonstrate that AIM2 is also involved in the activation of the inflammasome in response to the intracellular bacterium Listeria monocytogenes.
Luigi Franchi, Gabriel Núñez
openaire +3 more sources
AIM2 in regulatory T cells restrains autoimmune diseases
Nature, 2021 The inflammasome initiates innate defence and inflammatory responses by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It consists of an innate immune receptor/sensor, pro-caspase-1, and a common adaptor molecule, ASC. Consistent with their pro-inflammatory function, caspase-1, ASC and the inflammasome component NLRP3 exacerbate ...
Leslie Freeman +20 more
openaire +6 more sources
Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination [PDF]
, 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original ...
Lorenz, Alexander +3 more
core +1 more source
Brucella-induced activation of AIM2 inflammasome and Caspase-1 enhances IL-18 secretion in THP-1 cells [PDF]
Srpski Arhiv za Celokupno LekarstvoIntroduction/Objective. The purpose was to investigate the role of the inflammasome absent in melanoma 2 (AIM2) in Brucella-induced inflammatory responses in macrophages. Methods.
Li Yupu +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Intervertebral disc degeneration (IDD) is the primary cause of low back pain. Stress-induced DNA damage is closely relevant to the pathogenesis of IDD; however, the underlying mechanisms remain unclear.
Shuai Li +11 more
doaj +1 more source
IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]
, 2016 Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias +9 more
core +1 more source
Autoinflammation in Syndromic Hidradenitis Suppurativa: The Role of AIM2
Vaccines, 2023 Background: AIM2 is a key cytoplasmatic pathogen-sensor that detects foreign DNA from viruses and bacteria; it can also recognize damaged or anomalous presence of DNA, promoting inflammasome assembly and activation with the secretion of IL-1β, thus sustaining a chronic inflammatory state, potentially leading to the onset of autoinflammatory skin ...
Chiara Moltrasio +8 more
openaire +5 more sources
IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
core +1 more source