Results 51 to 60 of about 19,682 (247)

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor [PDF]

, 2016
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds
Altschul, Bassham, Baxt, Berrow, Birgisdottir, Boyle, Bozkurt, Bozkurt, Bozkurt, Caillaud, Chaparro-Garcia, Choy, Dagdas, Fisher, Geldner, Hanamata, He, Huang, Ivanov, Kalvari, Karimi, Kumar, Kwon, Lamb, Larkin, Lenz, Li, Lipka, Liu, Lv, Morgan, Mostowy, Oh, Patel, Petre, Randow, Randow, Saunders, Segonzac, Shintani, Song, Stolz, Svenning, Teh, Vanhee, Wang, Win, Yoshimoto, Zientara-Rytter   +48 more
core   +1 more source

The NLRP3 Inflammasome as a Novel Therapeutic Target for Cardiac Fibrosis

Journal of Inflammation Research, 2022
Jiwen Fan,1 Meng Ren,2 Binay Kumar Adhikari,3 Haodong Wang,1 Yuquan He1 1Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Medical Oncology, Jilin Provincial Cancer Hospital ...
Fan J, Ren M, Adhikari BK, Wang H, He Y
doaj  

Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease

Journal of Neuroinflammation, 2019
Cumulative evidence indicates that activation of innate immune responses in the central nervous system (CNS) induces the expression of type 1 interferons (T1 IFNs), a family of cytokines.
Divaker Choubey
doaj   +1 more source

ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]

, 2016
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr, Dick, Mathias S., Hiller, Sebastian, Rühl, Sebastian, Sborgi, Lorenzo   +4 more
core   +1 more source

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome [PDF]

, 2020
Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome ...
Atmosukarto, Ines I., Burgio, Gaetan, Feng, Shouya, Fox, Daniel, Fox, Edward M., Hayward, Jenni A., Jessberger, Nadja, Johnson, Matthew D., Kaakoush, Nadeem O., Leppla, Stephen H., Leyton, Denisse L., Liu, Yunqi, Man, Si Ming, Mathur, Anukriti, Märtlbauer, Erwin, Ngo, Chinh, Pandey, Abhimanu, Price, Jason D., Robertson, Avril A. B., Tan, Wei Hong, Tscharke, David C., Xue, Yansong   +21 more
core   +5 more sources

AIM2 inflammasome activation and regulation: A structural perspective [PDF]

Journal of Structural Biology, 2017
Absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic dsDNA and induces cytokine maturation, release and pyroptosis. It is composed of AIM2, apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1. Recent X-ray crystallographic and high resolution cryo-electron microscopic (cryo-
Bing Wang, Qian Yin
openaire   +3 more sources

Retracted: HBx‐mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis

Molecular Oncology, 2017
Tumor metastasis is responsible for the high mortality rates in patients with hepatocellular carcinoma (HCC). Absent in melanoma 2 (AIM2) has been implicated in inflammation and carcinogenesis, although its role in HCC metastasis remains unknown.
Shi‐Lu Chen, Li‐Li Liu, Shi‐Xun Lu, Rong‐Zhen Luo, Chun‐Hua Wang, Hong Wang, Shao‐Hang Cai, Xia Yang, Dan Xie, Chris Zhiyi Zhang, Jing‐Ping Yun   +10 more
doaj   +1 more source

Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy

Autophagy, 2023
Macroautophagy/autophagy plays an important role in regulating cellular homeostasis and influences the pathogenesis of degenerative diseases. Tendinopathy is characterized by tendon degeneration and inflammation. However, little is known about the role of selective autophagy in tendinopathy.
Huaji Jiang, Yingchao Xie, Jiansen Lu, Hongyu Li, Ke Zeng, Zhiqiang Hu, Dan Wu, Jianwu Yang, Zhenxia Yao, Huadan Chen, Xiaoqian Gong, Xiao Yu   +11 more
openaire   +2 more sources

Assembly mechanism of the inflammasome sensor AIM2 revealed by single molecule analysis

Nature Communications, 2023
Pathogenic dsDNA prompts AIM2 assembly leading to the formation of the inflammasome, a multimeric complex that triggers the inflammatory response. The recognition of foreign dsDNA involves AIM2 self-assembly concomitant with dsDNA binding.
Meenakshi Sharma, Eva de Alba
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources