Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes [PDF]
International Journal of Molecular Sciences, 2021 The inflammasome is a three-component (sensor, adaptor, and effector) filamentous signaling platform that shields from multiple pathogenic infections by stimulating the proteolytical maturation of proinflammatory cytokines and pyroptotic cell death.
Sharma, Meenakshi, de Alba, Eva
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Journal of Neuroinflammation, 2019 Cumulative evidence indicates that activation of innate immune responses in the central nervous system (CNS) induces the expression of type 1 interferons (T1 IFNs), a family of cytokines.
Divaker Choubey
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AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment [PDF]
Nature, 2020 Neurodevelopment is characterized by rapid rates of neural cell proliferation and differentiation followed by massive cell death in which more than half of all recently generated brain cells are pruned back. Large amounts of DNA damage, cellular debris, and by-products of cellular stress are generated during these neurodevelopmental events, all of ...
Catherine R. Lammert +8 more
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ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
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Retracted: HBx‐mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis
Molecular Oncology, 2017 Tumor metastasis is responsible for the high mortality rates in patients with hepatocellular carcinoma (HCC). Absent in melanoma 2 (AIM2) has been implicated in inflammation and carcinogenesis, although its role in HCC metastasis remains unknown.
Shi‐Lu Chen +10 more
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The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury [PDF]
, 2018 Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues containing actively proliferating cells, including bone marrow and the gastrointestinal tract.
Cetinbas, Naniye +15 more
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Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
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Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection [PDF]
, 2016 Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans.
Gurung, Prajwal +9 more
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Radionuclides proportion and radiological risk assessment of soil samples collected in Covenant University, Ota, Ogun State Nigeria [PDF]
, 2018 The activity levels of 238U, 232Th and 40K in soil surrounding major office complexes in Covenant University were analyzed for radiological hazards to determine the safety of the residents in such environment.
Adewoyin, O.O. +5 more
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AIM2 in health and disease: Inflammasome and beyond
Immunological Reviews, 2020 AbstractNucleic acid sensing is a critical mechanism by which the immune system monitors for pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial DNA in various compartments of the cell, such as endosomes, the cytosol, and the nucleus.
Puja Kumari +3 more
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