AIM2 deficiency reduces the development of hepatocellular carcinoma in mice [PDF]
International Journal of Cancer, 2018 Chronic liver inflammation is crucial in the pathogenesis of hepatocellular carcinoma (HCC). Activation of the inflammasome complex is a key inflammatory process that has been associated with different liver diseases, but its role in HCC development remains largely unexplored.
José Such +10 more
openaire +5 more sources
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection [PDF]
, 2016 Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans.
Gurung, Prajwal +9 more
core +1 more source
AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity
iScience, 2023 Summary: AIM2 is an interferon-inducible HIN-200 protein family member and is well-documented for its roles in innate immune responses as a DNA sensor.
Jefferson Antônio Leite +17 more
doaj +1 more source
Radionuclides proportion and radiological risk assessment of soil samples collected in Covenant University, Ota, Ogun State Nigeria [PDF]
, 2018 The activity levels of 238U, 232Th and 40K in soil surrounding major office complexes in Covenant University were analyzed for radiological hazards to determine the safety of the residents in such environment.
Adewoyin, O.O. +5 more
core +1 more source
IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. [PDF]
PLoS ONE, 2011 Type-I interferons (IFNs) are used to treat certain inflammatory diseases. Moreover, activation of type-I IFN-signaling in immune cells inhibits the production of proinflammatory cytokines and activation of inflammasomes.
Sudhakar Veeranki +4 more
doaj +1 more source
Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]
, 2017 Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio +10 more
core +1 more source
Cell Reports, 2018 Summary: Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity. Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however, the relative contribution of IFNs and inflammasome responses in ...
Qifan Zhu +4 more
doaj +1 more source
A novel pathway of cell death in response to cytosolic DNA in Drosophila cells [PDF]
, 2015 Defence against invading DNA occurs in both mammals and bacteria. Recognition of stray DNA can initiate responses to infection, but may also protect against potentially mutagenic integration of transposons or retrotransposons into the genome.
Johnson, Karyn\ua0N. +3 more
core +1 more source
Journal of Neuroinflammation, 2021 Background Activation of the absent in melanoma 2 (AIM2) inflammasome and impaired autophagosome clearance in neurons contribute significantly to cardiac arrest and return of spontaneous circulation (CA-ROSC) injury, while the mechanism by which the AIM2
Rongjiao Shao +4 more
doaj +1 more source
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age [PDF]
, 2015 Background: Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via ...
Böckler, Dittmar +5 more
core +1 more source