Results 71 to 80 of about 22,661 (290)

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury

Frontiers in Pharmacology
Background Edaravone dexborneol (Eda-Dex), a promising neuroprotectant composed of edaravone and (+)-borneol, has been clinically applied in stroke treatment. However, the mechanism of action of Eda-Dex remains unclear.
Hui Zhang, Can Zhu, Xin Zhou, Laifa Wang, Ling Deng, Binsheng He, Jianming Li   +6 more
semanticscholar   +1 more source

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. [PDF]

PLoS ONE, 2011
Type-I interferons (IFNs) are used to treat certain inflammatory diseases. Moreover, activation of type-I IFN-signaling in immune cells inhibits the production of proinflammatory cytokines and activation of inflammasomes.
Sudhakar Veeranki, Xin Duan, Ravichandran Panchanathan, Hongzhu Liu, Divaker Choubey   +4 more
doaj   +1 more source

AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity

iScience, 2023
Summary: AIM2 is an interferon-inducible HIN-200 protein family member and is well-documented for its roles in innate immune responses as a DNA sensor.
Jefferson Antônio Leite, Luísa Menezes, Eloisa Martins, Tamara Silva Rodrigues, Lucas Tavares, Anna Ebering, Carsten Schelmbauer, Guilherme C. Martelossi Cebinelli, Valeriya Zinina, Artemiy Golden, Natalia Soshnikova, Dario S. Zamboni, Fernando Q. Cunha, Magdalena Huber, João Santana Silva, Ari Waisman, Daniela Carlos, Niels Olsen Saraiva Câmara   +17 more
doaj   +1 more source

A novel pathway of cell death in response to cytosolic DNA in Drosophila cells [PDF]

, 2015
Defence against invading DNA occurs in both mammals and bacteria. Recognition of stray DNA can initiate responses to infection, but may also protect against potentially mutagenic integration of transposons or retrotransposons into the genome.
Johnson, Karyn\ua0N., Sester, David P., Stacey, Katryn\ua0J., Vitak, Nazarii   +3 more
core   +1 more source

Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection

Cell Reports, 2018
Summary: Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity. Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however, the relative contribution of IFNs and inflammasome responses in ...
Qifan Zhu, Si Ming Man, Rajendra Karki, R.K. Subbarao Malireddi, Thirumala-Devi Kanneganti   +4 more
doaj   +1 more source

The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest

Journal of Neuroinflammation, 2021
Background Activation of the absent in melanoma 2 (AIM2) inflammasome and impaired autophagosome clearance in neurons contribute significantly to cardiac arrest and return of spontaneous circulation (CA-ROSC) injury, while the mechanism by which the AIM2
Rongjiao Shao, Xintao Wang, Tianhua Xu, Yiyang Xia, Derong Cui   +4 more
doaj   +1 more source

Inflammatory caspases : key regulators of inflammation and cell death [PDF]

, 2014
The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel, Lamkanfi, Mohamed   +1 more
core   +2 more sources

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

MHF1–2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination [PDF]

, 2013
Peer reviewedPublisher ...
Bhattacharjee, Sonali, Bryer, Claire, Feeney, Laura, Lorenz, Alexander, Osman, Fekret, Whitby, Matthew C.   +5 more
core   +1 more source