Results 71 to 80 of about 19,682 (247)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

AIM2 as a putative target in acute kidney graft rejection

Frontiers in Immunology, 2022
Acute rejection (AR) is a process triggered via the recognition of grafted organ-derived antigens by the immune system, which could present as a life-threatening condition. In the context of a kidney transplant, despite improvement with immunosuppressive therapies, AR maintains a significant incidence of 10%, and currently available drugs generally act
Nathália Franchon Marques Tejada, João Vitor Ziroldo Lopes, Luis Eduardo Duarte Gonçalves, Izabela Mamede Costa Andrade da Conceição, Glória Regina Franco, Bruno Ghirotto, Niels Olsen Saraiva Câmara, Niels Olsen Saraiva Câmara   +7 more
openaire   +3 more sources

Inflammatory caspases : key regulators of inflammation and cell death [PDF]

, 2014
The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel, Lamkanfi, Mohamed   +1 more
core   +2 more sources

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

The role of AIM2 in inflammation and tumors

Frontiers in Immunology
Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory mediators and the cleavage of Gasdermins.
Dalang Yu, Siping Zheng, Siping Zheng, Lina Sui, Lina Sui, Yuling Xi, Yuling Xi, Tiansheng He, Zhiping Liu   +8 more
openaire   +3 more sources

Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly [PDF]

Journal of Biological Chemistry, 2013
AIM2 binds dsDNA and associates with ASC through their PYDs to form an inflammasome.The AIM2 PYD structure illustrates distinct charge distribution and a unique hydrophobic patch.The AIM2 PYD may bind the ASC PYD and the AIM2 HIN domain through overlapping surface.These findings provide insights into the mechanisms of AIM2 autoinhibition and ...
Jiansheng Jiang, Andrew J. Perry, Patrick T. Smith, Tengchuan Jin, T. Sam Xiao   +4 more
openaire   +3 more sources

AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis

Autoimmunity, 2022
The inflammasome AIM2 regulates multiple aspects of innate immune functions and serves as a critical mediator of inflammatory responses. AIM2 inflammasome activation leads to the production of pro-inflammatory cytokines, IL-1β and IL-18 and participates ...
E. E. Uresti-Rivera, M. H. García-Hernández   +1 more
doaj   +1 more source

Molecular Alterations and Association with Clinical Parameters [PDF]

, 2015
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR- DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa
Benner, Axel, Bläker, Hendrik, Echterdiek, Fabian, Grabe, Niels, Kloor, Matthias, Knebel Doeberitz, Magnus von, Lahrmann, Bernd, Nelius, Nina, Schneider, Martin, Staffa, Laura, Tariverdian, Mirjam, Werft, Wiebke   +11 more
core   +1 more source

GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation

Advanced Science, EarlyView.
Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo, Mingliang Ma, Dan Wang, Ling Luo, Xueming Xu, Lingmin Huang, Fupeng Wang, Guangyan Kuang, Huiqi Liu, Rui Ni, Xin Li, Qinghua Zhang, Shengfeng Wang, Kai Zhao   +13 more
wiley   +1 more source

LPS‐Induced Mitochondrial Damage via SLC41A1‐Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells

Advanced Science, EarlyView.
Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu, Chenyu Song, Liyuan Zhang, Xue Han, Chaoyuan Li, Yanhong Yan, Ludan Xing, Mengting Si, Bo Yang, Lingyuan Cheng, Akimi Muramatsu, Beizhan Jiang   +11 more
wiley   +1 more source