Results 81 to 90 of about 22,661 (290)
International Journal on Biological Sciences, 2023 Renal cell carcinoma (RCC) is a serious threat to people's health due to its rapid progression, and patients easily develop resistance to targeted therapy.
Qi Wang +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang +10 more
wiley +1 more source
Molecular Alterations and Association with Clinical Parameters [PDF]
, 2015 Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR- DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa
Benner, Axel +11 more
core +1 more source
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation [PDF]
Nature Communications, 2016 Abstract Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear.
Min Xie +12 more
openaire +3 more sources
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis
Autoimmunity, 2022 The inflammasome AIM2 regulates multiple aspects of innate immune functions and serves as a critical mediator of inflammatory responses. AIM2 inflammasome activation leads to the production of pro-inflammatory cytokines, IL-1β and IL-18 and participates ...
E. E. Uresti-Rivera +1 more
doaj +1 more source
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age [PDF]
, 2015 Background: Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via ...
Böckler, Dittmar +5 more
core +1 more source
Advanced Science, EarlyView.This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou +8 more
wiley +1 more source
Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders
Advanced Science, EarlyView.Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li +7 more
wiley +1 more source
AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes
Proceedings of the National Academy of Sciences, 2023 Malaria, caused by Plasmodium parasites is a severe disease affecting millions of people around the world. Plasmodium undergoes obligatory development and replication in the hepatocytes, before initiating the life-threatening blood-stage of malaria.
Camila Marques-da-Silva +13 more
openaire +2 more sources