Results 61 to 70 of about 383,906 (352)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Profiling of the Microbiome Associated With Nitrogen Removal During Vermifiltration of Wastewater From a Commercial Dairy. [PDF]

, 2018
Vermifiltration is a biological treatment process during which earthworms (e.g., Eisenia fetida) and microorganisms reduce the organic load of wastewater.
Hess, Matthias, Lai, Ellen, Mitloehner, Frank M   +2 more
core   +3 more sources

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Hemozoin induces neuronal injury primarily characterized by axon rupture and mitochondrial damage in experimental cerebral malaria

Parasites & Vectors
Background Cerebral malaria (CM) is the most serious and fatal neurological complication of Plasmodium falciparum infection, which can cause death or long-term neurological sequelae.
Tong Li, Dongmei Dang, Yan Shen, Jun Wang, Yuxiao Huang, Qinghao Zhu, Yi Wang, Chao Yang, Ganze Li, Jiayi Sun, Aining Zhang, Pengtao Li, Jiao Liang, Ya Zhao   +13 more
doaj   +1 more source

Characterization and Antimicrobial Activity of Hafnium Nanostructures Fabricated by Physical Vapor Deposition Through a Colloidal Mask

Advanced Materials Interfaces, EarlyView.
We generate hafnium nanostructures by first depositing polystyrene particles of varying diameter followed by physical vapour deposition of hafnium thin films. The resultant structure shows a kill‐on‐contact effect against both Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus.
Andrew Boden, Tzu‐Ying Liao, Tomas Katkus, Helmut Thissen, De Ming Zhu, Mrinal Bhave, Peter Kingshott   +6 more
wiley   +1 more source

Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria

Journal of Neuroinflammation
Background Cerebral malaria (CM) is the most lethal complication of malaria, and survivors usually endure neurological sequelae. Notably, the cytotoxic effect of infiltrating Plasmodium-activated CD8+ T cells on cerebral microvasculature endothelial ...
Yi Wang, Yan Shen, Jiao Liang, Shubiao Wang, Yuxiao Huang, Qinghao Zhu, Xizhi Zhang, Kangjie Yu, Guodong Tong, Chao Yang, Yinghui Li, Jun Wang, Ya Zhao   +12 more
doaj   +1 more source

Nitrous oxide production in soil isolates of nitrate-ammonifying bacteria [PDF]

, 2012
Here we provide the first demonstration of the potential for N2O production by soil-isolated nitrate-ammonifying bacteria under different C and N availabilities, building on characterizations informed from model strains.
Bamford, Bleakley, Cole, Costa, Cruz Ramos, Fazzolari, Gilberthorpe, Hussain, Iobbi-Nivol, Jepson, Jormakka, Kelso, Lane, Macdonald, Mohan, Nakano, Pett-Ridge, Pope, Potter, Sambrook, Schmidt, Silver, Silver, Simon, Smith, Smith, Smith, Stevens, Wan, Yin   +29 more
core   +2 more sources

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Bibliometric Analysis on Global Research Trends of Airborne Microorganisms in Recent Ten Years (2011–2020)

Aerosol and Air Quality Research, 2020
In recent years, exposure to bioaerosols—airborne particles of biological origin—has become a significant public health concern. Hence, this study aims to provide a bibliometric analysis of global trends in research on airborne microorganisms in the last
Yonghao Jia, Yihan Chen, Ping Yan, Qianli Huang   +3 more
doaj   +1 more source