Results 11 to 20 of about 832,675 (307)

Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria [PDF]

, 2013
Background:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g.
Bowler, RP, Chu, HW, Jiang, D, Schnell, C, Wenzel, SE, Wu, Q   +5 more
core   +21 more sources

Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]

, 2020
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J, Chen, Yuzhang, Darmanis, Spyros, He, Mu, Jan, Lily Yeh, Jan, Yuh Nung, Le, Daniel D, Li, Ke-Xin, Neff, Norma, Padovano, Valeria, Sinclair, Adriane W, Sit, Rene, Tan, Michelle, Wu, Bing, Ye, Wenlei   +14 more
core   +1 more source

Within-session variability as quality control for oscillometry in health and disease

ERJ Open Research, 2021
Oscillometry is increasingly adopted in respiratory clinics, but many recommendations regarding measurement settings and quality control remain subjective.
Louise M. Harkness, Kieran Patel, Farid Sanai, Sandra Rutting, Alice M. Cottee, Claude S. Farah, Robin E. Schoeffel, Gregory G. King, Cindy Thamrin   +8 more
doaj   +1 more source

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. [PDF]

, 2019
Congenital pulmonary airway malformation (CPAM) is the most common congenital lesion detected in the neonatal lung, which may lead to respiratory distress, infection, and pneumothorax.
Jiang, Yi, Lou, Jianlin, Luo, Yongfeng, Moats, Rex, Pryhuber, Gloria S, Shi, Wei, Tang, Yang, Wang, Larry L, Warburton, David, Zhou, Shengmei   +9 more
core   +3 more sources

Reduced Local Response to Corticosteroids in Eosinophilic Chronic Rhinosinusitis with Asthma

Biomolecules, 2020
Eosinophilic chronic rhinosinusitis (ECRS), a subgroup of chronic rhinosinusitis with nasal polyps, is recognized as a refractory eosinophilic disorder characterized by both upper and lower airway inflammation.
Yoshiki Kobayashi, Akira Kanda, Yasutaka Yun, Dan Van Bui, Kensuke Suzuki, Shunsuke Sawada, Mikiya Asako, Hiroshi Iwai   +7 more
doaj   +1 more source

On the Role of Mechanics in Chronic Lung Disease. [PDF]

, 2013
Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen.
Eskandari, Mona, Kuhl, Ellen, Pfaller, Martin R   +2 more
core   +3 more sources

Flow-volume curve analysis for predicting recurrence after endoscopic dilation of airway stenosis [PDF]

, 2019
The flow-volume curve is a simple test for diagnosing upper airway obstruction. We evaluated its use to predict recurrence in patients undergoing endoscopic dilation for treatment of benign upper airway ...
Andreetti, Claudio, Ardò, Nicoletta, Fiorelli, Alfonso, Loizzi, Domenico, Loizzi, Michele, Messina, Gaetana, Poggi, Camilla, Rendina, Erino Angelo, Santini, Mario, Serra, Nicola, Sollitto, Francesco, Venuta, Federico   +11 more
core   +1 more source

TGF-β1 Activates Nasal Fibroblasts through the Induction of Endoplasmic Reticulum Stress

Biomolecules, 2020
(1) Background: Tissue remodeling and extracellular matrix (ECM) accumulation contribute to the development of chronic inflammatory diseases of the upper airway.
Jae-Min Shin, Ju-Hyung Kang, Joo-Hoo Park, Hyun-Woo Yang, Heung-Man Lee, Il-Ho Park   +5 more
doaj   +1 more source

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. [PDF]

, 2013
Organophosphorus pesticides (OPs) are implicated in human asthma. We previously demonstrated that, at concentrations that do not inhibit acetylcholinesterase activity, the OP parathion causes airway hyperreactivity in guinea pigs as a result of ...
Allison D. Fryer, Becky J. Proskocil, Borish L, Crain EF, Crinnion WJ, David B. Jacoby, Donald A. Bruun, Gallo MA, Grodzki AC, Lu C, Nico van Rooijen, Pamela J. Lein, Rozyk KJ   +12 more
core   +1 more source

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]

, 2016
Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans, Grooten, Johan, Gustafsson, Jan-Ake, Lambrecht, Bart, Naessens, Thomas, Smet, Muriel, Steffensen, Knut R, Van Hoecke, Lien, Vander Beken, Seppe, Vergote, Karl, Willart, Monique   +10 more
core   +1 more source