Results 21 to 30 of about 1,180,011 (399)

Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity

Scientific Reports, 2021
Surfactant protein A (SP-A) is well-known for its protective role in pulmonary immunity. Previous studies from our group have shown that SP-A mediates eosinophil activities, including degranulation and apoptosis.
Alane Blythe C. Dy, Paul R. Langlais, Natalie K. Barker, Kenneth J. Addison, Sasipa Tanyaratsrisakul, Scott Boitano, Stephanie A. Christenson, Monica Kraft, Deborah Meyers, Eugene R. Bleecker, Xingnan Li, Julie G. Ledford   +11 more
doaj   +1 more source

Within-session variability as quality control for oscillometry in health and disease

ERJ Open Research, 2021
Oscillometry is increasingly adopted in respiratory clinics, but many recommendations regarding measurement settings and quality control remain subjective.
Louise M. Harkness, Kieran Patel, Farid Sanai, Sandra Rutting, Alice M. Cottee, Claude S. Farah, Robin E. Schoeffel, Gregory G. King, Cindy Thamrin   +8 more
doaj   +1 more source

Reduced Local Response to Corticosteroids in Eosinophilic Chronic Rhinosinusitis with Asthma

Biomolecules, 2020
Eosinophilic chronic rhinosinusitis (ECRS), a subgroup of chronic rhinosinusitis with nasal polyps, is recognized as a refractory eosinophilic disorder characterized by both upper and lower airway inflammation.
Yoshiki Kobayashi, Akira Kanda, Yasutaka Yun, Dan Van Bui, Kensuke Suzuki, Shunsuke Sawada, Mikiya Asako, Hiroshi Iwai   +7 more
doaj   +1 more source

Airway Remodeling in Asthma

Frontiers in Medicine, 2020
Asthma is an inflammatory disease of the airways that may result from exposure to allergens or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of breath.
Kenneth P. Hough, M. Curtiss, Trevor J Blain, Rui-ming Liu, J. Trevor, J. Deshane, V. Thannickal   +6 more
semanticscholar   +1 more source

On the Role of Mechanics in Chronic Lung Disease. [PDF]

, 2013
Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen.
Eskandari, Mona, Kuhl, Ellen, Pfaller, Martin R   +2 more
core   +3 more sources

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. [PDF]

, 2019
Congenital pulmonary airway malformation (CPAM) is the most common congenital lesion detected in the neonatal lung, which may lead to respiratory distress, infection, and pneumothorax.
Jiang, Yi, Lou, Jianlin, Luo, Yongfeng, Moats, Rex, Pryhuber, Gloria S, Shi, Wei, Tang, Yang, Wang, Larry L, Warburton, David, Zhou, Shengmei   +9 more
core   +3 more sources

Long‐term expanding human airway organoids for disease modeling

EMBO Journal, 2019
Organoids are self‐organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a method to establish long‐term‐expanding human airway organoids from broncho‐alveolar resections or ...
Norman Sachs, A. Papaspyropoulos, D. Z. Zomer-van Ommen, Inha Heo, L. Böttinger, Dymph Klay, F. Weeber, Guizela Huelsz-Prince, Nino Iakobachvili, G. Amatngalim, J. Ligt, A. Hoeck, Natalie Proost, M. Viveen, A. Lyubimova, Luc Teeven, Sepideh Derakhshan, J. Korving, H. Begthel, J. Dekkers, Kuldeep Kumawat, E. Ramos, Matthijs FM Oosterhout, G. Offerhaus, Dominique J Wiener, E. P. Olimpio, K. Dijkstra, E. Smit, Maarten Linden, S. Jaksani, M. Ven, J. Jonkers, A. Rios, E. Voest, Coline HM Moorsel, C. Ent, E. Cuppen, A. Oudenaarden, F. Coenjaerts, L. Meyaard, Louis J. Bont, P. Peters, S. Tans, J. S. Zon, S. Boj, R. Vries, J. Beekman, H. Clevers   +47 more
semanticscholar   +1 more source

Lower airway dysbiosis affects lung cancer progression.

Cancer Discovery, 2020
In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly occurs and ex vivo models support that some of these bacteria can trigger host transcriptomic signatures associated with carcinogenesis. Here, we show that this lower
Jun-Chieh J. Tsay, Benjamin G. Wu, I. Sulaiman, K. Gershner, Rosemary Schluger, Yonghua Li, T. Yie, P. Meyn, E. Olsen, L. Perez, B. Franca, J. Carpenito, T. Iizumi, M. El-Ashmawy, M. Badri, J. Morton, N. Shen, Linchen He, G. Michaud, S. Rafeq, J. Bessich, Robert L. Smith, H. Sauthoff, K. Felner, R. Pillai, Anastasia-Maria Zavitsanou, Sergei B Koralov, V. Mezzano, C. Loomis, A. Moreira, W. Moore, A. Tsirigos, A. Heguy, W. Rom, D. Sterman, H. Pass, J. Clemente, Huilin Li, Richard Bonneau, Kwok-kin Wong, T. Papagiannakopoulos, L. Segal   +41 more
semanticscholar   +1 more source

TGF-β1 Activates Nasal Fibroblasts through the Induction of Endoplasmic Reticulum Stress

Biomolecules, 2020
(1) Background: Tissue remodeling and extracellular matrix (ECM) accumulation contribute to the development of chronic inflammatory diseases of the upper airway.
Jae-Min Shin, Ju-Hyung Kang, Joo-Hoo Park, Hyun-Woo Yang, Heung-Man Lee, Il-Ho Park   +5 more
doaj   +1 more source

Flow-volume curve analysis for predicting recurrence after endoscopic dilation of airway stenosis [PDF]

, 2019
The flow-volume curve is a simple test for diagnosing upper airway obstruction. We evaluated its use to predict recurrence in patients undergoing endoscopic dilation for treatment of benign upper airway ...
Andreetti, Claudio, Ardò, Nicoletta, Fiorelli, Alfonso, Loizzi, Domenico, Loizzi, Michele, Messina, Gaetana, Poggi, Camilla, Rendina, Erino Angelo, Santini, Mario, Serra, Nicola, Sollitto, Francesco, Venuta, Federico   +11 more
core   +1 more source