Results 21 to 30 of about 484,101 (316)

HFA-BDP Metered-Dose Inhaler Exhaled Through the Nose Improves Eosinophilic Chronic Rhinosinusitis With Bronchial Asthma: A Blinded, Placebo-Controlled Study

Frontiers in Immunology, 2018
Background: Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis with nasal polyps in Japanese. ECRS highly associated with asthma is a refractory eosinophilic airway inflammation and requires comprehensive care as part of ...
Yoshiki Kobayashi, Yoshiki Kobayashi, Hirotaka Yasuba, Mikiya Asako, Mikiya Asako, Takahisa Yamamoto, Hiroshi Takano, Koichi Tomoda, Akira Kanda, Akira Kanda, Hiroshi Iwai   +10 more
doaj   +1 more source

Effect of Air Pollutants on Allergic Inflammation in Structural Cells of the Nasal Mucosa [PDF]

Clinical and Experimental Otorhinolaryngology
Objectives. Air pollution is an increasing global concern, and its effect on allergic inflammation has attracted the attention of many researchers. Particulate matter (PM) is a major component of ambient air pollution, and heavy metals are the primary ...
Joo-Hoo Park, Jee Won Moon, Hyun-Woo Yang, Dae Jin Song, Il-Ho Park   +4 more
doaj   +1 more source

Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer

Journal for ImmunoTherapy of Cancer, 2021
Background The interplay of immune and cancer cells takes place in the tumor microenvironment where multiple signals are exchanged. The transforming growth factor beta (TGFB) pathway is known to be dysregulated in lung cancer and can impede an effective ...
Sebastian Marwitz, Christian Kugler, Sven Perner, Daniel Drömann, Torsten Goldmann   +4 more
doaj   +1 more source

Association of blood total immunoglobulin E and eosinophils with radiological features of bronchiectasis

BMC Pulmonary Medicine, 2023
Background Our study aimed to investigate whether serum total IgE and blood eosinophils were associated with radiological features of bronchiectasis in a Chinese cohort.
Jiaqi Ren, Ai Chen, Jun Wang, Chun Chang, Juan Wang, Lina Sun, Yongchang Sun   +6 more
doaj   +1 more source

Patients Unmet Needs in Chronic Rhinosinusitis With Nasal Polyps Care: A Patient Advisory Board Statement of EUFOREA

Frontiers in Allergy, 2021
Background: European patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have had only limited occasions to unite to have their voices heard, hence missing the opportunity to contribute to the improvement of CRSwNP care.Aims: To identify ...
N. Claeys, M. T. Teeling, P. Legrand, M. Poppe, P. Verschueren, L. De Prins, L. Cools, L. Cypers, W. J. Fokkens, W. J. Fokkens, C. Hopkins, C. Hopkins, P. W. Hellings, P. W. Hellings, P. W. Hellings, P. W. Hellings   +15 more
doaj   +1 more source

Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

FASEB BioAdvances, 2019
Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD).
Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke, Sharon Tooze, Terje Johansen, Peter J. Barnes   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Geographic Differences in Availability and Access to Care Services for Asthma and COPD: Case Study of Vancouver Coastal Health, British Columbia

Canadian Respiratory Journal
Conclusion: Our findings suggest rural VCH communities have lower access to asthma and COPD care services and the limited urban care services were insufficient to make up for this difference.
Amelia Choy, Erin M. Shellington, Aneisha Collins-Fairclough, Nardia Strydom, Chris Carlsten   +4 more
doaj   +1 more source

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13)

EBioMedicine, 2017
Background: Rhinovirus infection is a major cause of asthma exacerbations. Objectives: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. Methods: We used nasosorption on days 0, 2–5
Trevor T. Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico del-Rosario, Jaideep Dhariwal, Paul D.W. Kirk, Michael P.H. Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M. Hunt, Trevor L. Hunt, Duncan G. Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J. Jackson, Sebastian L. Johnston   +25 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source