Results 31 to 40 of about 1,180,011 (399)

Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19), a predominantly respiratory illness.
Haijun Zhang, M. Rostami, P. Leopold, J. Mezey, S. O'Beirne, Y. Strulovici-Barel, R. Crystal   +6 more
semanticscholar   +1 more source

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Under the concept of "united airway diseases," the airway is a single organ wherein upper and lower airway diseases are commonly comorbid. The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance ...
H. Hong, Shumin Liao, Fenghong Chen, Qintai Yang, D. Wang   +4 more
semanticscholar   +1 more source

Patterns of recruitment and injury in a heterogeneous airway network model [PDF]

, 2015
In respiratory distress, lung airways become flooded with liquid and may collapse due to surface-tension forces acting on air-liquid interfaces, inhibiting gas exchange.
Cressoni M, Murphy SL, Oliver E. Jensen, Peter S. Stewart, The Acute Respiratory Distress Syndrome Network, Weibel ER   +5 more
core   +2 more sources

Inflammatory cytokines can be monitored in exhaled breath particles following segmental and inhalation endotoxin challenge in healthy volunteers

Scientific Reports, 2022
Particles in exhaled air (PEx) are generated when collapsed small airways reopen during breathing. PEx can be noninvasively collected by particle impaction, allowing the analysis of undiluted epithelial lining fluid (ELF).
Olaf Holz, Meike Müller, Saskia Carstensen, Anna-Carin Olin, Jens M. Hohlfeld   +4 more
doaj   +1 more source

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

bioRxiv, 2020
The derivation of self-renewing tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would shorten the time needed to engineer mature cell types in vitro and would have broad reaching implications for the field of regenerative ...
F. Hawkins, F. Hawkins, Shingo Suzuki, M. Beermann, Cristina Barillà, Ruobing Wang, C. Villacorta-Martin, A. Berical, A. Berical, J. Jean, Jake Le Suer, Jake Le Suer, C. Simone-Roach, Yang Tang, Thorsten M. Schlaeger, Thorsten M. Schlaeger, A. Crane, Sarah X. L. Huang, S. Randell, A. Rab, E. J. Sorscher, A. Horani, S. Brody, B. Davis, D. Kotton, D. Kotton   +25 more
semanticscholar   +1 more source

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. [PDF]

, 2013
Organophosphorus pesticides (OPs) are implicated in human asthma. We previously demonstrated that, at concentrations that do not inhibit acetylcholinesterase activity, the OP parathion causes airway hyperreactivity in guinea pigs as a result of ...
Allison D. Fryer, Becky J. Proskocil, Borish L, Crain EF, Crinnion WJ, David B. Jacoby, Donald A. Bruun, Gallo MA, Grodzki AC, Lu C, Nico van Rooijen, Pamela J. Lein, Rozyk KJ   +12 more
core   +1 more source

Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults

British Journal of Anaesthesia, 2015
These guidelines provide a strategy to manage unanticipated difficulty with tracheal intubation. They are founded on published evidence. Where evidence is lacking, they have been directed by feedback from members of the Difficult Airway Society and based
C. Frerk, V. Mitchell, A. McNarry, C. Mendonca, R. Bhagrath, Anil K Patel, E. O'sullivan, N. Woodall, I. Ahmad   +8 more
semanticscholar   +1 more source

Tensin1 expression and function in chronic obstructive pulmonary disease [PDF]

, 2019
open access articleChronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in ...
Amrani, Y., Bradding, Peter, Brightling, C. E., Clark, K., Gooptu, B., Roach, K.M., Smallwood, Dawn T., Stylianou, P.   +7 more
core   +1 more source

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]

, 2016
Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans, Grooten, Johan, Gustafsson, Jan-Ake, Lambrecht, Bart, Naessens, Thomas, Smet, Muriel, Steffensen, Knut R, Van Hoecke, Lien, Vander Beken, Seppe, Vergote, Karl, Willart, Monique   +10 more
core   +1 more source

Relationship between concavity of the flow-volume loop and small airway measures in smokers with normal spirometry

BMC Pulmonary Medicine, 2022
Background There is increasing evidence of small airway abnormalities in smokers despite normal spirometry. The concavity in the descending limb of the maximum expiratory flow curve (MEFV) is a recognised feature of obstruction and can provide ...
Hooria Alowiwi, Stella Watson, Kanika Jetmalani, Cindy Thamrin, David P. Johns, E. Haydn Walters, Gregory G. King   +6 more
doaj   +1 more source