Results 41 to 50 of about 783,276 (359)

Assessment of the Clinical Diagnosis of Onychomycosis by Dermoscopy

Frontiers in Surgery, 2022
BackgroundAs a common clinical superficial fungal infection, the diagnosis of onychomycosis relies on clinical features, traditional KOH direct microscopy and fungal culture. In recent years, dermoscopy has been widely used in the diagnosis and treatment
Yan Ma, Yan Ma, Ying Ji, Ying Ji, Wen Cen, Wen Cen, Zusha Qiao, Zusha Qiao, Yan Gao, Yan Gao, Lu He, Wenli Feng, Wenli Feng   +12 more
doaj   +1 more source

Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer

American Journal of Respiratory and Critical Care Medicine, 2018
Rationale: In lung cancer, upregulation of the PI3K (phosphoinositide 3‐kinase) pathway is an early event that contributes to cell proliferation, survival, and tissue invasion.
J. Tsay, Benjamin G. Wu, M. Badri, J. Clemente, N. Shen, P. Meyn, Yonghua Li, T. Yie, Tenzin W. Lhakhang, E. Olsen, V. Murthy, G. Michaud, I. Sulaiman, A. Tsirigos, A. Heguy, H. Pass, M. Weiden, W. Rom, D. Sterman, Richard Bonneau, M. Blaser, L. Segal   +21 more
semanticscholar   +1 more source

HFA-BDP Metered-Dose Inhaler Exhaled Through the Nose Improves Eosinophilic Chronic Rhinosinusitis With Bronchial Asthma: A Blinded, Placebo-Controlled Study

Frontiers in Immunology, 2018
Background: Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis with nasal polyps in Japanese. ECRS highly associated with asthma is a refractory eosinophilic airway inflammation and requires comprehensive care as part of ...
Yoshiki Kobayashi, Yoshiki Kobayashi, Hirotaka Yasuba, Mikiya Asako, Mikiya Asako, Takahisa Yamamoto, Hiroshi Takano, Koichi Tomoda, Akira Kanda, Akira Kanda, Hiroshi Iwai   +10 more
doaj   +1 more source

Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer

Journal for ImmunoTherapy of Cancer, 2021
Background The interplay of immune and cancer cells takes place in the tumor microenvironment where multiple signals are exchanged. The transforming growth factor beta (TGFB) pathway is known to be dysregulated in lung cancer and can impede an effective ...
Sebastian Marwitz, Christian Kugler, Sven Perner, Daniel Drömann, Torsten Goldmann   +4 more
doaj   +1 more source

Association of blood total immunoglobulin E and eosinophils with radiological features of bronchiectasis

BMC Pulmonary Medicine, 2023
Background Our study aimed to investigate whether serum total IgE and blood eosinophils were associated with radiological features of bronchiectasis in a Chinese cohort.
Jiaqi Ren, Ai Chen, Jun Wang, Chun Chang, Juan Wang, Lina Sun, Yongchang Sun   +6 more
doaj   +1 more source

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on the
Jie Zhou, Cun Li, Norman Sachs, M. Chiu, Bosco Ho-Yin Wong, Hin Chu, V. Poon, Dong Wang, Xiaoyu Zhao, Lei Wen, Wenjun Song, Shuofeng Yuan, K. K. Wong, J. Chan, K. To, Honglin Chen, H. Clevers, K. Yuen   +17 more
semanticscholar   +1 more source

Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

FASEB BioAdvances, 2019
Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD).
Nicolas Mercado, Thomas Colley, Jonathan R. Baker, Chaitanya Vuppussetty, Yuta Kono, Colin Clarke, Sharon Tooze, Terje Johansen, Peter J. Barnes   +8 more
doaj   +1 more source

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13)

EBioMedicine, 2017
Background: Rhinovirus infection is a major cause of asthma exacerbations. Objectives: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. Methods: We used nasosorption on days 0, 2–5
Trevor T. Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico del-Rosario, Jaideep Dhariwal, Paul D.W. Kirk, Michael P.H. Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M. Hunt, Trevor L. Hunt, Duncan G. Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J. Jackson, Sebastian L. Johnston   +25 more
doaj   +1 more source

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

Nature Methods, 2015
Here we describe the development of a human lung 'small airway-on-a-chip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying microvascular endothelium that experiences fluid flow, which allows for analysis of organ-level ...
K. Benam, Remi Villenave, C. Lucchesi, A. Varone, C. Hubeau, Hyun-Hee Lee, S. Alves, M. Salmon, Thomas C. Ferrante, J. Weaver, A. Bahinski, G. Hamilton, D. Ingber   +12 more
semanticscholar   +1 more source

The Emerging 4D Printing of Shape‐Memory Thermomorphs for Self‐Adaptative Biomedical Implants

Advanced Functional Materials, EarlyView.
4D printing enables the creation of smart implants that adapt to changing conditions in the human body over time. At the core of this technology are shape‐memory thermomorphs (SMTMs). This review offers an in‐depth analysis of 4D printing with SMTMs, emphasizing the latest advancements in smart materials, stimuli, programming principles, and their ...
Aixiang Ding, Fang Tang, Eben Alsberg
wiley   +1 more source