Results 61 to 70 of about 1,180,011 (399)

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13)

EBioMedicine, 2017
Background: Rhinovirus infection is a major cause of asthma exacerbations. Objectives: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. Methods: We used nasosorption on days 0, 2–5
Trevor T. Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico del-Rosario, Jaideep Dhariwal, Paul D.W. Kirk, Michael P.H. Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M. Hunt, Trevor L. Hunt, Duncan G. Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J. Jackson, Sebastian L. Johnston   +25 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on the
Jie Zhou, Cun Li, Norman Sachs, M. Chiu, Bosco Ho-Yin Wong, Hin Chu, V. Poon, Dong Wang, Xiaoyu Zhao, Lei Wen, Wenjun Song, Shuofeng Yuan, K. K. Wong, J. Chan, K. To, Honglin Chen, H. Clevers, K. Yuen   +17 more
semanticscholar   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Airway remodeling in asthma: what really matters

Cell and Tissue Research, 2017
Airway remodeling is generally quite broadly defined as any change in composition, distribution, thickness, mass or volume and/or number of structural components observed in the airway wall of patients relative to healthy individuals.
H. Fehrenbach, C. Wagner, M. Wegmann
semanticscholar   +1 more source

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. [PDF]

, 1996
Reversible airway hyperreactivity underlies the pathophysiology of asthma, yet the precise mediators of the response remain unclear. Human studies have correlated aberrant activation of T helper (Th) 2-like effector systems in the airways with disease. A
Corry, DB, Erle, DJ, Folkesson, HG, Locksley, RM, Matthay, MA, Warnock, ML, Wiener-Kronish, JP   +6 more
core  

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Dimensional Changes of Upper Airway after Rapid Maxillary Expansion: A Prospective Cone-beam Computed Tomography Study [PDF]

, 2013
Introduction: The aim of this prospective study was to use cone-beam computed tomography to assess the dimensional changes of the upper airway in orthodontic patients with maxillary constriction treated by rapid maxillary expansion.
Bosio, Jose A, Bradley, T. Gerard, Chang, Yoon Hwan, Koenig, Lisa J., Liu, Dawei, Pruszynski, Jessica E.   +5 more
core   +2 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Post Intubation Phonatory Insufficiency: A novel surgical treatment

Otolaryngology Case Reports, 2021
Post Intubation Phonatory Insufficiency as a result of prolonged intubation in premature neonates is a challenging condition to diagnose and treat.An endotracheal tube can cause an erosive injury to the medial surface of the arytenoid cartilage resulting
Bronagh Lang, Sara Dallape, Rania Mehanna, John Russell   +3 more
doaj   +1 more source