Results 61 to 70 of about 1,147,551 (385)

A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13)

EBioMedicine, 2017
Background: Rhinovirus infection is a major cause of asthma exacerbations. Objectives: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. Methods: We used nasosorption on days 0, 2–5
Trevor T. Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico del-Rosario, Jaideep Dhariwal, Paul D.W. Kirk, Michael P.H. Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M. Hunt, Trevor L. Hunt, Duncan G. Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J. Jackson, Sebastian L. Johnston   +25 more
doaj   +1 more source

Association of blood total immunoglobulin E and eosinophils with radiological features of bronchiectasis

BMC Pulmonary Medicine, 2023
Background Our study aimed to investigate whether serum total IgE and blood eosinophils were associated with radiological features of bronchiectasis in a Chinese cohort.
Jiaqi Ren, Ai Chen, Jun Wang, Chun Chang, Juan Wang, Lina Sun, Yongchang Sun   +6 more
doaj   +1 more source

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht, Edelmann, Martin, Fischer, Rainald, Huber, Rudolf M., Kellner, Julia, Oelmez, Hamza, Tantzscher, Juliane   +6 more
core   +1 more source

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on the
Jie Zhou, Cun Li, Norman Sachs, M. Chiu, Bosco Ho-Yin Wong, Hin Chu, V. Poon, Dong Wang, Xiaoyu Zhao, Lei Wen, Wenjun Song, Shuofeng Yuan, K. K. Wong, J. Chan, K. To, Honglin Chen, H. Clevers, K. Yuen   +17 more
semanticscholar   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Geographic Differences in Availability and Access to Care Services for Asthma and COPD: Case Study of Vancouver Coastal Health, British Columbia

Canadian Respiratory Journal
Conclusion: Our findings suggest rural VCH communities have lower access to asthma and COPD care services and the limited urban care services were insufficient to make up for this difference.
Amelia Choy, Erin M. Shellington, Aneisha Collins-Fairclough, Nardia Strydom, Chris Carlsten   +4 more
doaj   +1 more source

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L., Coltherd, J. C., Harnett, M. M., Harnett, W., Lawrie, R. E., Rodgers, D. T., Suckling, C. J.   +6 more
core   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Upper Airway Control in Airway Defense [PDF]

Acta Medica Martiniana, 2016
Abstract Upper airways (UA) are an organic component of the respiratory tract, they serve to respiration, respiratory tract protection and defense, phonation, deglutition, etc. The functions of UA are regulated by motor control of the oral, pharyngeal, and laryngeal muscles.
Jan Jakus, V Calkovsky, Ivan Poliacek, Michal Simera   +3 more
openaire   +3 more sources

A new role for exhaled nitric oxide as a functional marker of peripheral airway caliber changes: a theoretical study

, 2017
Though considered as an inflammation marker, exhaled nitric oxide (FENO) was shown to be sensitive to airway caliber changes to such an extent that it might be considered as a marker of them. It is thus important to understand how these changes and their
Haut, Benoît, Karamaoun, Cyril, Van Muylem, Alain   +2 more
core   +2 more sources