Results 71 to 80 of about 758,835 (312)

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on the
Jie Zhou, Cun Li, Norman Sachs, M. Chiu, Bosco Ho-Yin Wong, Hin Chu, V. Poon, Dong Wang, Xiaoyu Zhao, Lei Wen, Wenjun Song, Shuofeng Yuan, K. K. Wong, J. Chan, K. To, Honglin Chen, H. Clevers, K. Yuen   +17 more
semanticscholar   +1 more source

CCL4 Affects Eosinophil Survival via the Shedding of the MUC1 N-Terminal Domain in Airway Inflammation

Cells
Eosinophilic chronic rhinosinusitis (ECRS), a CRS with nasal polyps (CRSwNP), is characterized by eosinophilic infiltration with type 2 inflammation and is highly associated with bronchial asthma.
Yoshiki Kobayashi, Chu Hong Hanh, Naoto Yagi, Nhi Kieu Thi Le, Yasutaka Yun, Akihiro Shimamura, Kenta Fukui, Akitoshi Mitani, Kensuke Suzuki, Akira Kanda, Hiroshi Iwai   +10 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

‘The evidence is out there…’: perspectives of healthcare providers on improving asthma and COPD prevention and care within a major health authority region of British Columbia, Canada

BMJ Open Quality
Introduction Asthma and chronic obstructive pulmonary disease (COPD) impose substantial morbidity and health system burden in Canada. Within Vancouver Coastal Health (VCH), a large and geographically diverse health authority in British Columbia ...
Pat Camp, Karen Rideout, J Mark FitzGerald, Christopher Carlsten, John Fleetham, Nardia Strydom, Aneisha Collins-Fairclough, Phalgun Joshi, Tina Afshar, Erin Shellington, Sian Hoe Cheong, Mary-Frances Ceccato, Carmen Rempel   +12 more
doaj   +1 more source

Lonicera japonica‐Derived Nanovesicles Ameliorate Acute Lung Injury by Suppressing Neutrophil Extracellular Traps Formation in Mice

Advanced Healthcare Materials, EarlyView.
(A) Isolation and purification of LDNVs. (B) Establishment of the ALI model and LDNVs delivery. (C) Therapeutic mechanisms of LDNVs in treating ALI. This scheme figure was drawn by Figdraw, ID: IUIIO21222. ABSTRACT Acute lung injury (ALI) is a lethal respiratory disease.
Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang, Xinghua Liu, Hongying Cao, Huan Shen, Jianming Liang, Zhenhua Dai, Siyuan Xu, Xingdong Lin   +10 more
wiley   +1 more source

Role of inflammatory cells in airway remodeling in COPD

International Journal of COPD, 2018
COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema, leading to a progressive and irreversible decline in lung function. Inflammation is central for the development of COPD.
Yujie Wang, Jiayan Xu, Y. Meng, I. Adcock, X. Yao   +4 more
semanticscholar   +1 more source

Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ‐on‐Chip

Advanced Healthcare Materials, EarlyView.
A novel light‐based bioprinting approach, TVAM‐in‐a‐chip, enables rapid, contactless fabrication of biomimetic 3D organ‐on‐chip devices directly within preassembled microfluidic platforms. This strategy supports diverse materials, including cell‐laden resins, and eliminates post‐assembly steps.
Riccardo Rizzo, Viola Sgarminato, Felix Wechsler, Christophe Moser   +3 more
wiley   +1 more source

Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling

Cell Stem Cell, 2017
SUMMARY Effective derivation of functional airway organoids from induced pluripotent stem cells (iPSCs) would provide valuable models of lung disease and facilitate precision therapies for airway disorders such as cystic fibrosis.
Katherine B. McCauley, F. Hawkins, Maria Serra, Dylan C. Thomas, Anjali Jacob, D. Kotton   +5 more
semanticscholar   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology

Journal of Allergy and Clinical Immunology, 2018
&NA; Figure. No caption available. Background: Asthma pathophysiology and treatment responsiveness are predicted by inflammatory phenotype. However, the relationship between airway microbiology and asthma phenotype is poorly understood.
S. Taylor, L. Leong, J. Choo, S. Wesselingh, I. Yang, J. Upham, P. Reynolds, S. Hodge, A. James, C. Jenkins, M. Peters, M. Baraket, G. Marks, P. Gibson, J. Simpson, G. Rogers   +15 more
semanticscholar   +1 more source