Results 91 to 100 of about 110,250 (294)

Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial. [PDF]

, 2015
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD.
Alyn Morice, Amanda J. Lee, Andrew Briggs, Andrew Wilson, Anita Sullivan, Anthony De Soyza, B Shah, BG Cosio, BG Cosio, BR Celli, CM Fletcher, David Price, E Stahl, G Cusack, GC Donaldson, GC Donaldson, Gladys McPherson, Graham Burns, Graham Devereux, H Chrystyn, H Chrystyn, H Chrystyn, H Chrystyn, Henry Chrystyn, JA Marwick, JC Bestall, JJ Soler-Cataluna, JK Quint, John Haughney, John Norrie, JR Hurst, JR Powell, JR Powell, JW Dodd, K Ito, K Ito, K Ito, K Ito, K Ohta, KC Farmer, Kirsty McCormack, KL Hattotuwa, L Hendeles, Lisa Davies, M Britton, M Ferrer, MC Cyr, MR Miller, P Dolan, P Sullivan, PA Ford, Peter Barnes, PJ Barnes, PJ Barnes, PW Jones, Rekha Chaudhuri, RG Barr, S Lim, Seonaidh Cotton, Shona Fielding, Simon Gompertz, SN Hunt, SV Culpitt, SV Culpitt, TA Seemungal, The EuroQol Group, WJ Jusko, WJ Jusko, Y To   +68 more
core   +4 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Effects of second hand smoke on airway secretion and mucociliary clearance

Frontiers in Physiology, 2012
The airway acts as the first defense against inhaled pathogens and particulate matter from the environment. One major way for the airway to clear inhaled foreign objects is through mucociliary clearance (MCC), an important component of the respiratory ...
Yanyan eLiu, Yanyan eLiu, Y.Peter eDi
doaj   +1 more source

Hyaluronic acid: perspectives in upper aero-digestive tract. A systematic review [PDF]

, 2015
Background: To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT).
Baptista, Peter, Casale, Manuele, Moffa, Antonio, Oliveto, Giuseppe, Pace, Annalisa, Sabatino, Lorenzo, Salvinelli, Fabrizio, Vitali, Massimiliano   +7 more
core   +3 more sources

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

How mucosal epithelia deal with stress: Role of NKG2D/NKG2D ligands during inflammation [PDF]

, 2017
Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions.
Alessandra Soriani, Angela Santoni, Angela Santoni, Cristina Cerboni, Fabrizio Antonangeli, Giuseppe Sciumè   +5 more
core   +2 more sources

Airway Clearance in Bronchiectasis

, 2017
The chapter describes the bronchiectasis pathophysiology that informs and influences airways clearance techniques (ACT) and provides an overview of the aims of ACT and current practices in bronchiectasis. The main physiological mechanisms underlying ACTs as well as the current evidence base are detailed.
Bradley, Judy, O'Neill, Katherine, Vilaro, Jordi, McIlwaine, Maggie   +3 more
openaire   +2 more sources

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Yoshiharu Nakamura, Hiroshi Yoshida   +4 more
wiley   +1 more source