Results 51 to 60 of about 39,928 (244)

Mechanisms of Airway Remodeling in Asthma

Allergology International, 2007
Asthma is a chronic inflammatory disease characterized by reversible airflow limitation and airway hyperresponsiveness. Persistent inflammation in airway tissues may lead to structural changes known as airway remodeling and consequently airway ...
Etsuko Tagaya, Jun Tamaoki
doaj   +1 more source

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core  

Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund and is distributed by the Creative Commons CC-BY 3.0 license, under which all are free to reuse or distribute the article under the condition that this original publication ...
Anderson, SD, Bjermer, L, Kippelen, P, Romer, LM, Simpson, AJ, Tufvesson, E   +5 more
core   +2 more sources

Potential Biomarkers for Disease Stratification and Prognosis Prediction in Pediatric Asthma: LCN2, sST2 and FGF21

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric asthma is a common chronic airway inflammatory disease, where accurate assessment of disease severity and prognosis prediction is crucial for treatment decisions. Currently, there is a lack of precise and effective biomarkers.
Xu Yang, Hai Wang, Yong‐Zheng Zhang, Yan‐Yan Chen, Xin‐Xin Xing, Yi‐Cheng Ding   +5 more
wiley   +1 more source

The contribution of L-selectin to airway hyperresponsiveness in chronic allergic airways disease

Journal of Asthma and Allergy, 2010
Simon G Royce, Melissa Lee, Mimi L K TangDepartment of Allergy and Immunology, Murdoch Children’s Research Institute, The Royal Children’s Hospital, Parkville, Victoria 3052, AustraliaAbstract: L-selectin is a cell adhesion molecule ...
Simon G Royce, Melissa Lee, Mimi L K Tang   +2 more
doaj  

ETB receptor deficiency amplifies allergic airway inflammation and hyperresponsiveness

ERJ Open Research
Background Endothelin-1 (ET-1) is a proinflammatory mediator that plays a crucial role in regulating airway tone by activating G protein-coupled endothelin receptors A (ETA) and B (ETB).
Christoph Tabeling, Carla R. González Calera, Birgitt Gutbier, Laura Michalick, Carl-Friedrich Hocher, Katharina Ahrens, Jan Naujoks, Julia Herbert, Lynn J. Savic, Matthias Felten, Bastian Opitz, Hartwig Schütte, Wolfgang M. Kuebler, Thomas Tschernig, Berthold Hocher, Martin Witzenrath   +15 more
doaj   +1 more source

Three-dimensional bronchial tree visualization in exercise-induced severe asthma following tezepelumab treatment

Journal of Allergy and Clinical Immunology: Global
Airway hyperresponsiveness, a key feature of asthma, is associated with exercise-induced asthma. Tezepelumab was reported to reduce airway hyperresponsiveness.
Yoshiro Kai, MD, PhD, Yuichi Hishida, RT
doaj   +1 more source

GliSODin® prevents airway inflammation by inhibiting T-cell differentiation and activation in a mouse model of asthma

Frontiers in Allergy, 2023
BackgroundAsthma is a chronic inflammatory airway disease characterized by a prevailing type 2 inflammation, airway hyperresponsiveness, and mucus hypersecretion and is driven by various factors among which oxidative molecules, called reactive oxygen ...
Martin Klein, Eleonore Dijoux, Marie-Aude Cheminant, Laurent Intes, Grégory Bouchaud   +4 more
doaj   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Remodelling and Inflammation in Bronchial Asthma

European Journal of Inflammation, 2003
Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal accumulation of basophils, eosinophils, lymphocytes, mast cells, macrophages, dendritic cells and myofibroblasts.
G. Riccioni, N. D'Orazio, R. Della Vecchia, T. Iezzi, C. Di Ilio   +4 more
doaj   +1 more source