Results 221 to 230 of about 1,027,405 (258)

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Integrated approach to menopausal hormone therapy in women with cardiovascular risk factors or established ischemic heart disease, from early treatment initiation and risk stratification to individualized therapy, multidisciplinary follow‐up, and health‐system recommendations.
Chiara Benedetto, Martha Gulati, Suvarna S. Khadilkar, Angela H. E. M. Maas, Federica Frezet, Gláucia Maria Moraes de Oliveira, Andrea R. Genazzani, Hema Divakar, Athena Poppas, on behalf of the World Heart Federation (WHF) and the International Federation of Gynecology and Obstetrics (FIGO)   +9 more
wiley   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation. [PDF]

J Exp Med
Alcaraz-Serna A, Chillier N, Trompette A, Ermellino L, Porret R, Lana E, Cecchin R, Shanmuganathan A, Guney S, Alfageme-Abello O, Pace E, Mancarella A, Campos J, Foglierini M, von Garnier C, Fenwick C, Perez L, Ubags N, Muller YD.   +18 more
europepmc   +1 more source

Artificial intelligence models Traditional Chinese Medicine principles to integrate with biomedicine

iMeta, EarlyView.
Using 26,339 model‐eligible Traditional Chinese Medicine (TCM) formula records, we trained an autoencoder following TCM's compression–expansion logic to learn the TCM embedding space (TCM‐ES), quantifying symptom‐pattern–formula mappings. TCM‐ES aligns with conventional TCM principles not used in training.
Haoran Li, Xingye Cheng, Ziyang Huang, Jingyuan Luo, Qianqian Xu, Qiguang Zhao, Tianchen Guo, Yumeng Zhang, Linda L. D. Zhong, Zhaoxiang Bian, Leihan Tang, Aiping Lyu, Liang Tian   +12 more
wiley   +1 more source

Helper T cells and chemokines in elderly asthma - Mechanisms of airway inflammation and remodeling: A review. [PDF]

Biomol Biomed
Wu Y.
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

H3K18 lactylation promotes allergic airway inflammation in asthma via a CSF1/CSF1R/MAPK autocrine axis. [PDF]

Respir Res
Hu M, Chen Y, Huang H, Zhuo J, Zhong H, Liu D, Yu Q, Du Y, Zhang J, Cai S, Dong H.   +10 more
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

KAT8 drives M2 macrophage polarization to exacerbate allergic airway inflammation. [PDF]

iScience
Lai X, Li H, Zhao Z, Zhong Y, Su G, Huang J, Xiang Y, Huang R, Quan J, Feng Z, Fang Z, Li S, Huang T, Xiong Z, Lei Y, Zhang W, Duan J, Gao X, Lai T.   +18 more
europepmc   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source