Results 221 to 230 of about 162,572 (266)
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Mechanism of Airway Inflammation in Asthma
American Review of Respiratory Disease, 1993Abstract Airway inflammation has emerged as an important contributor to mechanisms of asthma. Furthermore, the presence of airway inflammation is present even in the absence of severe symptoms. To study the mechanisms by which bronchial inflammation can occur in asthma, a number of models have been developed including the airway ...
W W, Busse, W F, Calhoun, J D, Sedgwick
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Epigenetic regulation of airway inflammation
Current Opinion in Immunology, 2007Diverse cellular functions including the regulation of inflammatory gene expression, DNA repair and cell proliferation are regulated by epigenetic changes. Transcriptional co-activators possess intrinsic histone acetyltransferase (HAT) activity, and histone acetylation plays a major role in inflammatory gene expression.
Ian M, Adcock +3 more
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Macrolides and airway inflammation in children
Paediatric Respiratory Reviews, 2005For more than 20 years macrolide antibiotics have been used to treat chronic inflammatory airway diseases based on their immunomodulatory activity. Macrolide antibiotics down-regulate damaging prolonged inflammation as well as increase mucus clearance, decrease bacterial virulence and prevent biofilm formation. Initially shown to decrease morbidity and
Masaharu, Shinkai, Bruce K, Rubin
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Airway inflammation and remodeling in asthma
Current Opinion in Pulmonary Medicine, 2000An important advance in our understanding of the pathophysiology of asthma has been the discovery that airway inflammation is not confined to severe asthma but also characterizes mild and moderate asthma. Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes secrete cytokines that orchestrate ...
J V, Fahy, D B, Corry, H A, Boushey
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Assessment of airway inflammation: an overview.
The European respiratory journal. Supplement, 1998review
FABBRI, Leonardo +4 more
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Airway Inflammation and Inflammatory Biomarkers
Seminars in Respiratory and Critical Care Medicine, 2018AbstractSevere asthma is a complex disease consisting of different endotypes with different inflammatory and clinicopathological characteristics due to the heterogeneity of immune responses and smooth muscle dysfunction. There is an unmet clinical need to develop and to validate biomarkers that can differentiate between the asthma endotypes and guide ...
Hui Fang, Lim, Parameswaran, Nair
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CFTR is a modulator of airway inflammation
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007although it has been 17 years since the identification of the cystic fibrosis transmembrane ion receptor (CFTR) gene and protein, it remains enigmatic how abnormalities in CFTR can cause chronic and persistent pulmonary infection and inflammation that lead to bronchiectasis and end-stage ...
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Invasive monitoring of airway inflammation
Medical Journal of Australia, 2002What we know: Ethical concerns have limited research involving invasive bronchoscopy techniques in young children. No longitudinal studies have been conducted to compare the findings of bronchial biopsy or bronchoalveolar lavage in young children with transient episodic wheeze versus asthma.
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Inflammation and remodelling in the ageing airway
Medical Journal of Australia, 2005WHAT WE NEED TO KNOW: What changes occur in atopic and non-atopic airway inflammation in asthma with increasing age? What is the relationship between wound healing and airway remodelling in older subjects? What is the response to anti-inflammatory therapy in older subjects?
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