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Current Allergy and Asthma Reports, 2005
Several genes, including ADAM33, DPP10, PHF11, GPRA, and TIM-1, have been implicated in the pathogenesis and susceptibility to atopy and asthma. Advances have been made in defining the mechanism for the control of allergic airway inflammation in response to inhaled antigens.
Devendra K, Agrawal, Arpita, Bharadwaj
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Several genes, including ADAM33, DPP10, PHF11, GPRA, and TIM-1, have been implicated in the pathogenesis and susceptibility to atopy and asthma. Advances have been made in defining the mechanism for the control of allergic airway inflammation in response to inhaled antigens.
Devendra K, Agrawal, Arpita, Bharadwaj
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Cytokines in airway inflammation
The International Journal of Biochemistry & Cell Biology, 2000With over 50 potential asthma mediators, cytokines are the latest group of substances which have been investigated for their potential role in this disease. The use of murine models of allergic inflammation has facilitated the investigation of the role of individual cytokines in this response.
Riffo-Vasquez, Y, Pitchford, S, Spina, D
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Cytokines and Airway Inflammation
Annals of the New York Academy of Sciences, 199476662
Howarth, PH +4 more
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Aging Clinical and Experimental Research, 2013
Since little is known of airways inflammation in the elderly, we have carried out a study to explore the presence of some inflammatory markers in the airways of healthy subjects of different ages using a non-invasive method which is particularly suitable for aged people.The aim of this work was to investigate whether parameters, including (1) pH, IL-8 ...
Carpagnano, G. E. +4 more
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Since little is known of airways inflammation in the elderly, we have carried out a study to explore the presence of some inflammatory markers in the airways of healthy subjects of different ages using a non-invasive method which is particularly suitable for aged people.The aim of this work was to investigate whether parameters, including (1) pH, IL-8 ...
Carpagnano, G. E. +4 more
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Airway Inflammation in Childhood Asthma
American Journal of Respiratory and Critical Care Medicine, 2003Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other than asthma.
BARBATO, ANGELO +10 more
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Neuroimmune pathways regulating airway inflammation
Annals of Allergy, Asthma & Immunology, 2023Airways diseases are typically accompanied by inflammation, which has long been known to contribute to obstruction, mucus hypersecretion, dyspnea, cough, and other characteristic symptoms displayed in patients. Clinical interventions, therefore, often target inflammation to reverse lung pathology and reduce morbidity.
Pedro Trevizan-Bau, Stuart B. Mazzone
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Neurogenic Inflammation in Airways
International Archives of Allergy and Immunology, 1991Neurogenic inflammation, due to release of neuropeptides from sensory nerves, has been demonstrated in airways of several species, particularly rodents, and may contribute to the inflammatory response in asthmatic airways. Tachykinins (substance P and neurokinin A) and calcitonin-gene-related peptide released from airway sensory nerves may cause ...
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Purinergic Regulation of Airway Inflammation
2011The immune and inflammatory responses initiated by the interaction of a pathogen with airway surfaces constitute vital mechanisms to eradicate an infection. Sentinel dendritic cells embedded in the mucosa migrate to the lymph nodes to induce immune responses, whereas epithelial cells release chemokines to recruit inflammatory cells engaged in the ...
M. KOEPPEN +3 more
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Adiposity, asthma, and airway inflammation
Journal of Allergy and Clinical Immunology, 2007Several studies have found obesity to be associated with an increased prevalence of asthma. For reasons that remain unclear, this association has often been reported to be stronger in women than in men. One possible explanation might be that these studies have used body mass index to identify adiposity, which might be a less reliable measure of body ...
Christene R, McLachlan +10 more
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Airway Inflammation and Inflammatory Biomarkers
Seminars in Respiratory and Critical Care Medicine, 2018AbstractSevere asthma is a complex disease consisting of different endotypes with different inflammatory and clinicopathological characteristics due to the heterogeneity of immune responses and smooth muscle dysfunction. There is an unmet clinical need to develop and to validate biomarkers that can differentiate between the asthma endotypes and guide ...
Hui Fang, Lim, Parameswaran, Nair
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