Results 41 to 50 of about 396,951 (299)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Importance of slow vital capacity in the detection of airway obstruction

Jornal Brasileiro de Pneumologia, 2013
OBJECTIVE: To investigate the presence of airway obstruction by determining the FEV1/FVC and FEV1/slow vital capacity (SVC) ratios. METHODS: This was a quantitative, retrospective cross-sectional study.
Ana Raquel Goncalves de Barros, Margarida Batista Pires, Nuno Miguel Ferreira Raposo   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The role of FEV6 in the detection of airway obstruction

, 2005
Objectives: There are recent reports regarding the use of forced expiratory volume in 6 s (FEV6) in place of forced expiratory vital capacity (FVC) in the detection of airway obstruction. We aimed to investigate the role of FEV6 in comparison with FVC in
Demir, Tunçalp, Koc, W, YILDIRIM, N, IKITIMUR, Hande   +3 more
core   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Challenges in diagnosis and management of central airway obstruction: Case series

SAGE Open Medical Case Reports
Central airway obstruction often presents with respiratory symptoms identical to those of common respiratory diseases. Diagnosis of central airway obstruction is challenging in clinical practice, especially misdiagnosed as asthma or chronic obstructive ...
Bao Le-Khac, Khoa Nguyen-Dang, Nam Vu-Hoai, Nam Nguyen-Thanh, Ngoc Duong-Minh, Thai-Hoa Tran-Ngoc, Lam Nguyen-Ho   +6 more
doaj   +1 more source

Upper airways obstruction [PDF]

British Journal of Sports Medicine, 2000
The tongue falling backwards and blocking the nasopharynx is the commonest cause of upper airway obstruction. However, it may be due to blood, vomit, oedema, or trauma. The mouth should be inspected and any foreign material removed manually or by suction. There are three manoeuvres to improve upper airway obstruction. 1. Head tilt.
openaire   +2 more sources

Characteristics of patients with central airway obstruction.

, 2014
Characteristics of patients with central airway obstruction.
Hiroki Nishine (617310), Takeo Inoue (617311), Teruomi Miyazawa (617312), Hirotaka Kida (555666), Hiroshi Handa (7692), Masamichi Mineshita (617309)   +5 more
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Variable expiratory airflow, and not airway obstruction, is the defining physiological feature of asthma

Monaldi Archives for Chest Disease
Asthma is usually diagnosed by history and presence of airway obstruction with a significant bronchodilator response on spirometry. However, airway obstruction may not always be present, or a bronchodilator response may not be significant.
Sunil K. Chhabra
doaj   +1 more source