Results 131 to 140 of about 240,500 (234)

Diaphragm Ultrasonography Reveals Progressive Changes in Diaphragmatic Function, Morphology, and Muscle Trophism During Invasive Mechanical Ventilation in Children

Journal of Clinical Ultrasound, EarlyView.
Diaphragm ultrasonography detected progressive structural and functional deterioration in mechanically ventilated children. Prolonged invasive mechanical ventilation and neuromuscular blocking agent use were associated with ventilator‐induced diaphragmatic dysfunction, highlighting ultrasound as a valuable bedside tool to support individualized ...
Juliana Bezerra dos Santos, Emmerson Carlos Franco de Farias, Mary Lucy Ferraz Maia Fiuza de Mello, Rodrigo Santiago Barbosa Rocha   +3 more
wiley   +1 more source

Mechanism of RNA‐Binding Protein ELAVL1 in Promoting Th2 Cell Differentiation Through Stabilizing CPA3 mRNA in Allergic Rhinitis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to elucidate the role of the RNA‐binding protein embryonic lethality abnormal vision‐like protein 1 (ELAVL1) in the pathogenesis of allergic rhinitis (AR), specifically by investigating its potential to promote T helper 2 (Th2) cell differentiation by regulating the stability of carboxypeptidase A3 (CPA3) mRNA.
Meng‐Ya Liu, Hong‐Bing Yao, Cheng Chen   +2 more
wiley   +1 more source

Mechanisms of Airway Remodelling [PDF]

, 2008
Asthma is an inflammatory disease characterised by tissue remodelling. A prominent feature of this remodelling is an increase in the number and size of the blood vessels- formed from pre-existing capillaries – angiogenesis (Siddiqui et al., 2007; Wilson,
Boustany, Sarah
core  

Effect of Notch1 on Vocal Fold Re‐Epithelization After Acute Injury

The Laryngoscope, EarlyView.
Conditional deletion of Notch1 in Lrig1‐expressing vocal fold epithelial cells impaired re‐epithelialization following naphthalene injury, resulting in sustained basal cell proliferation, abnormal epithelial differentiation, and prolonged inflammatory cell infiltration.
Jie Cai, Susan L Thibeault, Vlasta Lungova   +2 more
wiley   +1 more source

Evaluating the Local Response of a Novel Injectable Capsule for Drug Delivery in the Trachea

The Laryngoscope, EarlyView.
A novel PLGA polymer capsule was developed for localized pretracheal drug delivery and evaluated for short‐term local tissue safety in a rabbit model. Implant placement was confirmed by ultrasound and was well tolerated over 14 days, with preservation of airway patency, native tracheal architecture, and biomechanical properties.
Denzel Ryan D. Cruz, Nour Awad, Nicholas Russell, Juliana El Sheikh, Logan Obermeyer, Peter J. Larson, Yoonjee C. Park, Gregory R. Dion   +7 more
wiley   +1 more source

Therapeutic JAK Inhibition in Idiopathic Subglottic Stenosis

The Laryngoscope, EarlyView.
Three patients with idiopathic subglottic stenosis and rheumatoid arthritis began JAK inhibitor therapy, after which the mean surgical‐free interval between endoscopic dilations rose from 317 to 631 days and the annualized dilation rate fell from 1.24 to 0.38 per patient‐year. Figure 2 shows this as a per‐patient timeline.
Riley M. Larkin, Ioan Lina, Julianna Kostas, Caroline Christmann, Kevin Byram, Alexander Gelbard   +5 more
wiley   +1 more source

Novel Injectable Supports Long‐Term Recurrent Laryngeal Nerve and Partial Peripheral Nerve Repair

The Laryngoscope, EarlyView.
Following recurrent laryngeal nerve transection in C57BL/6 mice, intramuscular Agrin, neuregulin‐1, and acetylcholine treatment of the thyroarytenoid muscle supported functional reinnervation and preservation of neuromuscular structure at 84 days.
Aditya Bhatt, William Boswell, Elena Kennedy, Sunjay Anekal, Emma Mazurek, Ananya Tadikonda, Christopher Rafalko, Jasmine Strelow, Isaac Shipchandler, Patrick R. Finnegan, Stacey Halum   +10 more
wiley   +1 more source

Differences in the Evaluation and Diagnosis of Obstructive Sleep Apnea by Sex: A Systematic Review

The Laryngoscope, EarlyView.
This systematic review of 33 studies found that females with obstructive sleep apnea generally presented at an older age and with higher BMI, whereas males generally had greater neck circumference and apnea‐hypopnea index. These findings highlight clinically relevant sex‐based differences in OSA evaluation and support more individualized approaches to ...
Alexandra Vacaru, Nihal A. Punjabi, Adebimpe Adebowale, Jaimie J. Park, Ronik Kothari, Philipp Verpukhovskiy, Jared C. Inman   +6 more
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Spatial transcriptomics reveals airway remodelling and molecular targets across COPD severity. [PDF]

ERJ Open Res
Yang CX, Rojas-Quintero J, Gerayeli FV, Polverino F, Ng RT, Malo J, Sin DD.   +6 more
europepmc   +1 more source